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Review
. 2022 Nov 15;23(22):14098.
doi: 10.3390/ijms232214098.

Extracellular Vesicles as Players in the Anti-Inflammatory Inter-Cellular Crosstalk Induced by Exercise Training

Giulia Catitti  1   2 , Domenico De Bellis  1   2 , Simone Vespa  1   2 , Pasquale Simeone  1   2 , Barbara Canonico  3 , Paola Lanuti  1   2
Affiliations
Review

Extracellular Vesicles as Players in the Anti-Inflammatory Inter-Cellular Crosstalk Induced by Exercise Training

Giulia Catitti et al. Int J Mol Sci. .

Abstract

Extracellular Vesicles (EVs) are circulating particles surrounded by a plasma membrane carrying a cargo consisting of proteins, lipids, RNAs, and DNA fragments, stemming from the cells from which they originated. EV factors (i.e., miRNAs) play relevant roles in intercellular crosstalk, both locally and systemically. As EVs increasingly gained attention as potential carriers for targeted genes, the study of EV effects on the host immune response became more relevant. It has been demonstrated that EVs regulate the host immune response, executing both pro- and anti-inflammatory functions. It is also known that physical exercise triggers anti-inflammatory effects. This review underlines the role of circulating EVs as players in the anti-inflammatory events associated with the regulation of the host's immune response to physical exercise.

Keywords: extracellular vesicles; inflammation; physical exercise.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Physical exercise and anti-inflammatory effects of EVs. Physical exercise induces the release of EVs of different origins. It has been demonstrated that exercise training induces the secretion of EVs stemming from skeletal muscle cells that carry anti-inflammatory signaling molecules (miRNAs and cytokines). Once released, (leukocyte-, muscle-, and platelet-derived EVs) EVs act locally and systemically reaching target tissues throughout blood circulation. EVs produced by physical exercise therefore act as anti-inflammatory agents.
See this image and copyright information in PMC

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