BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

doi:10.3390/ijms232214445

Review

. 2022 Nov 21;23(22):14445.

doi: 10.3390/ijms232214445.

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Susana Cubillos¹, Olivia Engmann¹, Anna Brancato²

Affiliations

¹ Institute for Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany.
² Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.

PMID: 36430921
PMCID: PMC9698349
DOI: 10.3390/ijms232214445

Review

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Susana Cubillos et al. Int J Mol Sci. 2022.

. 2022 Nov 21;23(22):14445.

doi: 10.3390/ijms232214445.

Authors

Susana Cubillos¹, Olivia Engmann¹, Anna Brancato²

Affiliations

¹ Institute for Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany.
² Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.

PMID: 36430921
PMCID: PMC9698349
DOI: 10.3390/ijms232214445

Abstract

Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.

Keywords: BDNF; TrkB; antidepressants; depression; environment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
The paradigm shift in antidepressants’ mechanism of action: focus on TrkB. Chronic monoaminergic antidepressants (AD) increase hippocampal and cortical BDNF levels promoting autocrine/paracrine mechanisms, which include the direct interaction with TrkB and CREB-mediated upregulation in serotonergic terminals. Created with BioRender.com.

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References

1. Malhi G.S., Mann J.J. Depression. Lancet. 2018;392:2299–2312. doi: 10.1016/S0140-6736(18)31948-2. - DOI - PubMed
1. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron. 2002;34:13–25. doi: 10.1016/S0896-6273(02)00653-0. - DOI - PubMed
1. Moncrieff J., Moncrieff J., Cooper R.E., Stockmann T., Amendola S., Hengartner M.P., Horowitz M.A. The serotonin theory of depression: A systematic umbrella review of the evidence. Mol. Psychiatry. 2022:1–14. doi: 10.1038/s41380-022-01661-0. - DOI - PMC - PubMed
1. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 1995;15:7539–7547. doi: 10.1523/JNEUROSCI.15-11-07539.1995. - DOI - PMC - PubMed
1. Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 1997;54:597–606. doi: 10.1001/archpsyc.1997.01830190015002. - DOI - PubMed

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[1] Malhi G.S., Mann J.J. Depression. Lancet. 2018;392:2299–2312. doi: 10.1016/S0140-6736(18)31948-2. - DOI - PubMed

[2] Malhi G.S., Mann J.J. Depression. Lancet. 2018;392:2299–2312. doi: 10.1016/S0140-6736(18)31948-2. - DOI - PubMed

[3] Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron. 2002;34:13–25. doi: 10.1016/S0896-6273(02)00653-0. - DOI - PubMed

[4] Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron. 2002;34:13–25. doi: 10.1016/S0896-6273(02)00653-0. - DOI - PubMed

[5] Moncrieff J., Moncrieff J., Cooper R.E., Stockmann T., Amendola S., Hengartner M.P., Horowitz M.A. The serotonin theory of depression: A systematic umbrella review of the evidence. Mol. Psychiatry. 2022:1–14. doi: 10.1038/s41380-022-01661-0. - DOI - PMC - PubMed

[6] Moncrieff J., Moncrieff J., Cooper R.E., Stockmann T., Amendola S., Hengartner M.P., Horowitz M.A. The serotonin theory of depression: A systematic umbrella review of the evidence. Mol. Psychiatry. 2022:1–14. doi: 10.1038/s41380-022-01661-0. - DOI - PMC - PubMed

[7] Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 1995;15:7539–7547. doi: 10.1523/JNEUROSCI.15-11-07539.1995. - DOI - PMC - PubMed

[8] Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 1995;15:7539–7547. doi: 10.1523/JNEUROSCI.15-11-07539.1995. - DOI - PMC - PubMed

[9] Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 1997;54:597–606. doi: 10.1001/archpsyc.1997.01830190015002. - DOI - PubMed

[10] Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression. Arch. Gen. Psychiatry. 1997;54:597–606. doi: 10.1001/archpsyc.1997.01830190015002. - DOI - PubMed

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BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Affiliations

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

Authors

Affiliations

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Conflict of interest statement

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