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Review
. 2022 Nov 14;11(22):6727.
doi: 10.3390/jcm11226727.

Deep Endometriosis and Infertility: What Is the Impact of Surgery?

Angelos Daniilidis  1 , Stefano Angioni  2 , Stefano Di Michele  2 , Konstantinos Dinas  1 , Fani Gkrozou  3 , Maurizio Nicola D'Alterio  2
Affiliations
Review

Deep Endometriosis and Infertility: What Is the Impact of Surgery?

Angelos Daniilidis et al. J Clin Med. .

Abstract

In women with deep endometriosis, the spontaneous fertility rate might range from 2 to 10%. The optimal management of these women is still an area of debate. Therefore, this review aims to explore the literature on the impact of deep endometriosis surgery on reproductive outcomes and pregnancy rates in women with and without prior infertility. A total of 392 articles were identified through database searching. Twenty-three studies were eligible to be included in the review. A total of 1548 women were identified, 814 of whom became pregnant, with a mean pregnancy rate of 52.6% (95% CI 49.7-63%). Our review suggests that surgery may improve fertility outcomes. Due to the variability in the studies, it is impossible to stratify fertility outcomes of surgery by the localization of deep endometriosis. More investigations are needed to determine whether surgical management should be first-intention or limited to the failure of medically assisted reproduction treatment.

Keywords: ART; MAR; deep endometriosis; infertility; surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study identification and selection.
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