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. 2022 Nov 21;27(22):8073.
doi: 10.3390/molecules27228073.

Adsorptive Capacity, Inhibitory Activity and Processing Techniques for a Copper-MOF Based on the 3,4-Dihydroxybenzoate Ligand

Estitxu Echenique-Errandonea  1 , Sara Rojas  2 , Víctor Karim Abdelkader-Fernández  2 , Manuel Pérez-Mendoza  2 , Ricardo F Mendes  3 , Paula Barbosa  4 , Filipe Figueiredo  4 , Flávio Figueira  3 , Filipe A Almeida Paz  3 , José Manuel Delgado-López  2 , Antonio Rodríguez-Diéguez  2 , José Manuel Seco  1
Affiliations

Adsorptive Capacity, Inhibitory Activity and Processing Techniques for a Copper-MOF Based on the 3,4-Dihydroxybenzoate Ligand

Estitxu Echenique-Errandonea et al. Molecules. .

Abstract

Due to the fast, emerging development of antibiotic-resistant bacteria, the need for novel, efficient routes to battle these pathogens is crucial; in this scenario, metal-organic frameworks (MOFs) are promising materials for combating them effectively. Herein, a novel Cu-MOF-namely 1-that displays the formula [Cu3L2(DMF)2]n (DMF = N,N-dimethylformamide) is described, synthesized by the combination of copper(II) and 3,4-dihydroxybenzoic acid (H3L)-both having well-known antibacterial properties. The resulting three-dimensional structure motivated us to study the antibacterial activity, adsorptive capacity and processability of the MOF in the form of pellets and membranes as a proof-of-concept to evaluate its future application in devices.

Keywords: adsorption capacity; antibacterial activity; material processing; metal-organic frameworks.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the asymmetric unit in [Cu3L2(DMF)2]n (1), emphasizing the disorder present in the coordinated DMF molecule and the inversion centre present in the Cu2 atom. Metal centre coordination environments were generated using the symmetry transformation (i) x + 3/2, y + 1/2, −z + 1/2; (ii) x + 1/2, −y + 3/2, z + 1/2; (iii) −x + 2, −y + 2, −z + 1; (iv) x − 1/2, − y + 3/2, z − 1/2; (v) – x + 1, y, − z + 1/.
Figure 2
Figure 2
Representation of the (a) coordination environment present for the two crystallographically independent Cu2+ cations, exhibiting a square pyramid and a octahedral coordination sphere (for Cu1 and Cu2, respectively) and (b) the inorganic chain with a “ABBA” connectivity between the metal centres extending along the (011) plane present in [Cu3L2(DMF)2]n (1).
Figure 3
Figure 3
Structural packing of [Cu3L2(DMF)2]n (1) as viewed in the (001) direction, alongside its topological view. The disorder present in the DMF molecule was removed for clarity.
Figure 4
Figure 4
N2 and CO2 adsorption and desorption isotherms at 77 K and 273 K of 1 upon outgassing at 170 °C for 6 h after solvent exchange with EtOH.
Figure 5
Figure 5
Diffusion assays showing the inhibitory activity against S. aureus of copper nitrate, H3L (ligand) and compound 1. The negative control sample—without inhibitory activity—contained calcium phosphate, which was also used as a supporting material in the rest of the samples (25 mg of active compound and 75 mg of calcium phosphate).
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