Effect of ECOG performance status on outcomes in patients with acute myeloid leukemia and other high-grade myeloid neoplasms

Gabrielle Paras¹, Megan Othus², Kelda Schonhoff¹, Carole Shaw³, Mohamed Sorror^{1

3}, Anna B Halpern^{1

3}, Jacob Appelbaum¹, Paul Hendrie¹, Roland B Walter^{1

3

4

5}, Elihu H Estey^{1

3}, Mary-Elizabeth M Percival^{6

7}

Affiliations

¹ Department of Medicine, University of Washington, Seattle, WA, USA.
² Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
³ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
⁴ Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
⁵ Department of Epidemiology, University of Washington, Seattle, WA, USA.
⁶ Department of Medicine, University of Washington, Seattle, WA, USA. mperciva@uw.edu.
⁷ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. mperciva@uw.edu.

Gabrielle Paras et al. Leukemia. 2023 Jan.

. 2023 Jan;37(1):231-234.

doi: 10.1038/s41375-022-01745-4. Epub 2022 Nov 25.

¹ Department of Medicine, University of Washington, Seattle, WA, USA.
² Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
³ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
⁴ Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
⁵ Department of Epidemiology, University of Washington, Seattle, WA, USA.
⁶ Department of Medicine, University of Washington, Seattle, WA, USA. mperciva@uw.edu.
⁷ Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. mperciva@uw.edu.

No abstract available

Conflict of interest statement

The authors declare no competing interests.

1. Kantarjian H, O’Brien S, Cortes J, Giles F, Faderl S, Jabbour E, et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer. 2006;106:1090–8. doi: 10.1002/cncr.21723. - DOI - PubMed
1. Walter RB, Othus M, Borthakur G, Ravandi F, Cortes JE, Pierce SA, et al. Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignment. J Clin Oncol. 2011;29:4417–23. doi: 10.1200/JCO.2011.35.7525. - DOI - PMC - PubMed
1. Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE, et al. Age and acute myeloid leukemia. Blood. 2006;107:3481–5. doi: 10.1182/blood-2005-09-3724. - DOI - PMC - PubMed
1. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–55. doi: 10.1097/00000421-198212000-00014. - DOI - PubMed
1. Dohner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Buchner T, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017;129:424–47.. doi: 10.1182/blood-2016-08-733196. - DOI - PMC - PubMed