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. 2022 Nov 24;12(1):20274.
doi: 10.1038/s41598-022-24090-z.

Green tea and coffee consumption and risk of kidney cancer in Japanese adults

Yichi Chen  1 , Sarah K Abe  2 , Manami Inoue  3   4 , Taiki Yamaji  5 , Motoki Iwasaki  4   5 , Shuhei Nomura  1   6   7 , Masahiro Hashizume  1 , Shoichiro Tsugane  4   8 , Norie Sawada  4 ; JPHC Study Group
Collaborators, Affiliations

Green tea and coffee consumption and risk of kidney cancer in Japanese adults

Yichi Chen et al. Sci Rep. .

Abstract

The study aimed to evaluate the association between green tea and coffee consumption and the risk of kidney cancer using data from a large prospective cohort study in Japan (the Japan Public Health Center-based Prospective Study: JPHC Study). A total of 102,463 participants aged 40-69 were followed during 1,916,421 person-years (mean follow-up period, 19 years). A total of 286 cases of kidney cancer (199 in men, 87 in women) were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) while adjusting for potential confounders. No statistically significant association between green tea intake and kidney cancer risk was found in the total population. Among women who consumed more than five cups of green tea per day, a statistically significant decreased risk was shown with a HR of 0.45 (95% CI: 0.23-0.89), compared to women who rarely consumed green tea. For coffee consumption, the association of kidney cancer risk was not statistically significant. This large prospective cohort study indicated green tea intake may be inversely associated with kidney cancer risk in Japanese adults, particularly in Japanese women.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier survival curves of the cumulative incidence of kidney cancer among JPHC participants with different green tea consumption.
Figure 2
Figure 2
Kaplan–Meier survival curves of the cumulative incidence of kidney cancer among JPHC participants with different coffee consumption.
See this image and copyright information in PMC

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