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Review
. 2023 Jan;25(1):43-66.
doi: 10.1007/s40272-022-00545-8. Epub 2022 Nov 25.

Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review

Elizabeth A Hall  1 , Hope H Brandon  2 , Hilary M Jasmin  3 , Kavitha C Raghavan  4 , Doralina L Anghelescu  5
Affiliations
Review

Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review

Elizabeth A Hall et al. Paediatr Drugs. 2023 Jan.

Abstract

In recent years, there has been increased interest in using gabapentinoids (gabapentin and pregabalin) as part of multimodal medication plans or enhanced recovery after surgery protocols to mitigate several perioperative clinical challenges. Outcomes explored in the context of using gabapentinoids perioperatively in children are variable and include acute complications of pain, anxiety, nausea and vomiting, and emergence agitation, as well as the long-term postoperative outcome of chronic postsurgical pain. This narrative review describes the current literature regarding perioperative use of gabapentinoids in pediatric patients and aims to describe the role of gabapentinoids in the perioperative setting for each specific indication.

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Conflict of interest statement

Conflict of Interest Elizabeth A. Hall, Hope H. Brandon, Hilary M. Jasmin, Kavitha C. Raghavan, and Doralina L. Anghelescu have no conflicts of interest that are directly relevant to the content of this article.

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