Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains

Harshvardhan Gazula^#¹, Kelly Rootes-Murdy^#², Bharath Holla^{3

4}, Sunitha Basodi², Zuo Zhang⁵, Eric Verner², Ross Kelly², Pratima Murthy⁶, Amit Chakrabarti⁷, Debasish Basu⁸, Subodh Bhagyalakshmi Nanjayya⁸, Rajkumar Lenin Singh⁹, Roshan Lourembam Singh¹⁰, Kartik Kalyanram¹¹, Kamakshi Kartik¹¹, Kumaran Kalyanaraman¹², Krishnaveni Ghattu¹², Rebecca Kuriyan¹³, Sunita Simon Kurpad¹⁴, Gareth J Barker¹⁵, Rose Dawn Bharath¹⁶, Sylvane Desrivieres⁵, Meera Purushottam¹⁷, Dimitri Papadopoulos Orfanos¹⁸, Eesha Sharma¹⁹, Matthew Hickman²⁰, Mireille Toledano²¹, Nilakshi Vaidya^{22

23}, Tobias Banaschewski²⁴, Arun L W Bokde²⁵, Herta Flor^{26

27}, Antoine Grigis¹⁸, Hugh Garavan²⁸, Penny Gowland²⁹, Andreas Heinz³⁰, Rüdiger Brühl³¹, Jean-Luc Martinot³², Marie-Laure Paillére Martinot^{32

33}, Eric Artiges^{32

34}, Frauke Nees^{23

24

26}, Tomás Paus^{35

36}, Luise Poustka³⁷, Juliane H Fröhner³⁸, Lauren Robinson³⁹, Michael N Smolka³⁸, Henrik Walter³⁰, Jeanne Winterer^{30

40}, Robert Whelan⁴¹; IMAGEN Consortium; Jessica A Turner^{2

42}, Anand D Sarwate⁴³, Sergey M Plis^{2

44}, Vivek Benegal⁶, Gunter Schumann^{5

23

45}, Vince D Calhoun^{2

42}

Affiliations

¹ Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, USA. hvgazula@umich.edu.
² Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
³ Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. hollabharath@gmail.com.
⁴ Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. hollabharath@gmail.com.
⁵ Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, SE5 8AF, United Kingdom.
⁶ Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
⁷ ICMR-Center on Non-communicable Diseases, Kolkata, India.
⁸ Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
⁹ Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur, India.
¹⁰ Department of Psychology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
¹¹ Rural Health Centre, Rishi Valley, Andhra Pradesh, India.
¹² Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
¹³ Division of Nutrition, St John's Research Institute, Bengaluru, India.
¹⁴ Department of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bangalore, India.
¹⁵ Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
¹⁶ Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, India.
¹⁷ Molecular Genetics Laboratory, NIMHANS, Bengaluru, India.
¹⁸ NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
¹⁹ Department of Child & Adolescent Psychiatry, NIMHANS, Bengaluru, India.
²⁰ Bristol Medical School, University of Bristol, Bristol, UK.
²¹ MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
²² Centre for Addiction Medicine, NIMHANS, Bengaluru, India.
²³ Centre for Population Neuroscience and Precision Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
²⁴ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany.
²⁵ Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
²⁶ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
²⁷ Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, 68131, Germany.
²⁸ Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, 05405, USA.
²⁹ Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
³⁰ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
³¹ Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.
³² Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli;, Gif-sur-Yvette, France.
³³ AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
³⁴ Psychiatry Department, EPS Barthélémy Durand, Etampes, France.
³⁵ Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
³⁶ Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada.
³⁷ Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, Göttingen, 37075, Germany.
³⁸ Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
³⁹ Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
⁴⁰ Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
⁴¹ School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁴² Department of Psychology, Georgia State University, Atlanta, GA, USA.
⁴³ Department of Electrical and Computer Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
⁴⁴ Department of Computer Science, Georgia State University, Atlanta, GA, USA.
⁴⁵ Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China.

^# Contributed equally.

PMID: 36434478
DOI: 10.1007/s12021-022-09604-4

Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains

Harshvardhan Gazula et al. Neuroinformatics. 2023 Apr.

. 2023 Apr;21(2):287-301.

doi: 10.1007/s12021-022-09604-4. Epub 2022 Nov 25.

Authors

Affiliations

¹ Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, USA. hvgazula@umich.edu.
² Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
³ Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. hollabharath@gmail.com.
⁴ Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. hollabharath@gmail.com.
⁵ Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, SE5 8AF, United Kingdom.
⁶ Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
⁷ ICMR-Center on Non-communicable Diseases, Kolkata, India.
⁸ Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
⁹ Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur, India.
¹⁰ Department of Psychology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
¹¹ Rural Health Centre, Rishi Valley, Andhra Pradesh, India.
¹² Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
¹³ Division of Nutrition, St John's Research Institute, Bengaluru, India.
¹⁴ Department of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bangalore, India.
¹⁵ Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
¹⁶ Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, India.
¹⁷ Molecular Genetics Laboratory, NIMHANS, Bengaluru, India.
¹⁸ NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
¹⁹ Department of Child & Adolescent Psychiatry, NIMHANS, Bengaluru, India.
²⁰ Bristol Medical School, University of Bristol, Bristol, UK.
²¹ MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
²² Centre for Addiction Medicine, NIMHANS, Bengaluru, India.
²³ Centre for Population Neuroscience and Precision Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
²⁴ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany.
²⁵ Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
²⁶ Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
²⁷ Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, 68131, Germany.
²⁸ Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, 05405, USA.
²⁹ Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
³⁰ Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
³¹ Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.
³² Institut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli;, Gif-sur-Yvette, France.
³³ AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
³⁴ Psychiatry Department, EPS Barthélémy Durand, Etampes, France.
³⁵ Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
³⁶ Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada.
³⁷ Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, Göttingen, 37075, Germany.
³⁸ Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
³⁹ Department of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
⁴⁰ Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
⁴¹ School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
⁴² Department of Psychology, Georgia State University, Atlanta, GA, USA.
⁴³ Department of Electrical and Computer Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
⁴⁴ Department of Computer Science, Georgia State University, Atlanta, GA, USA.
⁴⁵ Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China.

^# Contributed equally.

PMID: 36434478
DOI: 10.1007/s12021-022-09604-4

Abstract

With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks. In this study, we implement the neuromark pipeline in COINSTAC, an open-source neuroimaging framework for collaborative/decentralized analysis. Decentralized exploratory analysis of nearly 2000 resting-state functional magnetic resonance imaging datasets collected at different sites across two cohorts and co-located in different countries was performed to study the resting brain functional network connectivity changes in adolescents who smoke and consume alcohol. Results showed hypoconnectivity across the majority of networks including sensory, default mode, and subcortical domains, more for alcohol than smoking, and decreased low frequency power. These findings suggest that global reduced synchronization is associated with both tobacco and alcohol use. This proof-of-concept work demonstrates the utility and incentives associated with large-scale decentralized collaborations spanning multiple sites.

Keywords: Adolescent health; COINSTAC; CVEDA; Decentralized analysis; IMAGEN; Neuromark.

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References

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Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains

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Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains

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