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Published Erratum
. 2022 Nov 25;13(1):522.
doi: 10.1186/s13287-022-03207-1.

Correction: Expansion of mouse castration-resistant intermediate prostate stem cells in vitro

Yalan Xu  1   2 , Jie Mu  3 , Zhixia Zhou  1 , Yu Leng  1   2 , Yali Yu  1   2 , Xiuyue Song  1   2 , Aihua Liu  3 , Hai Zhu  4 , Jing Li  5 , Dong Wang  6
Affiliations
Published Erratum

Correction: Expansion of mouse castration-resistant intermediate prostate stem cells in vitro

Yalan Xu et al. Stem Cell Res Ther. .
No abstract available

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Figures

Fig. 2
Fig. 2
Marker expression of mouse CRIPSCs. The prostate epithelial cells isolated from WT mice at P0 (7 days) (A and B) and P5 (2 months) (C–J) were immunostained by the antibodies against CK8 (A and C), CK18 (B and D), AR (E), KLK* (*mouse KLK homologous protein recognized by the PSA/KLK3 antibody) (F), E-cadherin (G), CK5 (H), p63 (I), and Sox2 (J). DAPI-stained nuclei. Scale bars, 100 μm
Fig. 4
Fig. 4
Organoid formation in vitro. A Phase-contrast images of the organoids formed by the CRIPSCs (P25, 6 months) derived from WT and TRAMP mice. B Quantification of organoid diameter. Data were presented as mean ± SD. Two-way ANOVA was performed on the data, followed by Bonferroni post hoc tests. ***p < 0.001. C–E, Immunofluorescence images of the organoids stained by the antibodies against CK8, CK18, KLK* (*mouse KLK homologous protein recognized by the PSA/KLK3 antibody), p63, CK5, and Sox2. DAPI-stained nuclei. Scale bars, 100 μm
Fig. 5
Fig. 5
Differentiation of mouse CRIPSCs in vivo. The CRIPSCs (P25, 6 months) isolated from TRAMP mice were transplanted into NOG mice for eight weeks, followed by cryosection and immunostaining (A–H). The antibodies included CK8 (A), CK18 (B), AR (C), KLK* (*mouse KLK homologous protein recognized by the PSA/KLK3 antibody) (D), CK5 (E), p63 (F), Chromogranin A (CHGA) (G), Synaptophysin (SYP) (H). DAPI-stained nuclei. Scale bars, 100 μm
Fig. 7
Fig. 7
AR and KLK* (*mouse KLK homologous protein recognized by the PSA/KLK3 antibody) regulation by androgen deprivation and enzalutamide treatment. Western blots and quantifications of AR and KLK* of WT (A–C) and TRAMP (D–F) CRIPSCs (P25, 6 months) treated with different concentrations of DHT and enzalutamide (Enza) for one month. Data were presented as mean ± SD. One-way ANOVA was performed on the data, followed by Bonferroni post hoc tests. *p < 0.05. **p < 0.01. ***p < 0.001
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