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. 2023 Jun;43(6):1849-1859.
doi: 10.1007/s10792-022-02584-z. Epub 2022 Nov 27.

Analysis of risk factors for dry eye disease and effect of diquafosol sodium ophthalmic solution on the tear film after vitrectomy in patients with type 2 diabetes mellitus: a preliminary study

Xing Du  1 , Zhen Yang  1 , Yuanyuan Guo  1 , Shanshan Li  1 , Xu Wang  1 , Yanjuan Sheng  1 , Min Du  2
Affiliations

Analysis of risk factors for dry eye disease and effect of diquafosol sodium ophthalmic solution on the tear film after vitrectomy in patients with type 2 diabetes mellitus: a preliminary study

Xing Du et al. Int Ophthalmol. 2023 Jun.

Abstract

Purpose: The purpose of this study was to investigate the risk factors of DM associated dry eye syndrome (DMDES) and to explore the effect of diquafosol sodium ophthalmic solution (DQS) on patients with DMDES after vitrectomy.

Methods: Totally 107 patients (107 eyes) received vitrectomy. The data of age, gender, left/right eye, duration of DM, duration of vitrectomy, fasting blood glucose and glycosylated hemoglobin were collected and analyzed for correlation between these factors and DMDES. Postoperatively, DQS was instilled in experimental group and sodium hyaluronate was instilled in control group. The noninvasive breakup time (NIBUT), tear meniscus height (TMH), Schirmer I test (SIT), corneal fluorescence staining score (CFSS) and ocular surface disease index (OSDI) were recorded before vitrectomy and 1, 2 and 3 months after vitrectomy. All data were used for statistical comparison.

Results: Gender, duration of DM and glycosylated hemoglobin were relevant factors of DMDES (P < 0.05). At 1, 2 and 3 months postoperatively, NIBUT and TMH of experimental group were significantly higher than control group (P < 0.05). Postoperatively, CFSS of experimental group was lower than that before vitrectomy, and CFSS at 2 and 3 months after vitrectomy was significantly different between the two groups (P < 0.05). At 1, 2 and 3 months postoperatively, SIT increased in both groups, but there was no significant difference between the two groups (P > 0.05). OSDI was significantly lower in experimental group at 1, 2 and 3 months postoperatively, compared with that of the control group (P < 0.05).

Conclusion: These results suggest that gender, duration of DM and glycosylated hemoglobin are risk factors for DMDES. Postoperative instillation of DQS can improve the tear film quality in patients with DMDES after vitrectomy.

Keywords: Diabetes mellitus; Diquafosol sodium; Dry eye; Tear film; Vitrectomy.

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References

    1. International Diabetes Federation (2021) IDF Diabetes Atlas. 10th ed. International Diabetes Federation
    1. Messmer EM (2015) The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int 112:71–81 - PubMed - PMC
    1. Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE et al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15:438–510 - PubMed - DOI
    1. Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ et al (2009) 10-year follow-up of diabetes incidence and weight loss in the diabetes prevention program outcomes study. Lancet 374:1677–1686 - PubMed - DOI
    1. Yazdani-Ibn-Taz MK, Han MM, Jonuscheit S, Collier A, Nally JE, Hagan S (2019) Patient-reported severity of dry eye and quality of life in diabetes. Clin Ophthalmol 13:217–224 - PubMed - PMC - DOI

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