Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;52(12):2172-2175.
doi: 10.1111/imj.15954. Epub 2022 Nov 27.

Low mortality in vaccinated immunocompromised haematology patients infected with SARS-CoV-2

Briony Shaw  1   2 , Jake Shortt  1   2 , Michael Low  1   2 , Benjamin Rogers  1   3 , Zane Kaplan  1   2 , Pasquale Fedele  1   2 , Gareth Gregory  1   2 , Shahla Vilcassim  1   2 , Michael Gilbertson  1   2 , George Grigoriadis  1   2 , Stephen Opat  1   2
Affiliations

Low mortality in vaccinated immunocompromised haematology patients infected with SARS-CoV-2

Briony Shaw et al. Intern Med J. 2022 Dec.

Abstract

Coronavirus disease 2019 (COVID-19) infection in patients with haematological neoplasms has been associated with increased mortality; however, many studies in this patient group were reported early in the pandemic. The authors evaluated outcomes of COVID-19 infection in patients with haematological conditions following widespread vaccination, newer viral variants and increasingly effective antiviral therapies. A 4% mortality rate was found and contemporary risk factors for hospitalisation including older age, nonvaccination or partial COVID-19 vaccination status and infection with non-Omicron strain were identified.

Keywords: COVID-19; cancer; haematological malignancy; haematological neoplasm; vaccination.

PubMed Disclaimer

References

    1. Lee LYW, Cazier JB, Starkey T, Briggs SEW, Arnold R, Bisht V et al. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study. Lancet Oncol 2020; 21: 1309-16.
    1. Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020; 584: 430-6.
    1. Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B et al. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood 2020; 136: 2881-92.
    1. Passamonti F, Cattaneo C, Arcaini L, Bruna R, Cavo M, Merli F et al. Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study. Lancet Haematol 2020; 7: e737-45.
    1. Booth S, Curley HM, Varnai C, Arnold R, Lee LYW, Campton NA. Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy. Br J Haematol 2022; 196: 892-901.

Substances

LinkOut - more resources