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Review
. 2023 Apr 1;28(2):110-116.
doi: 10.1097/MOT.0000000000001040. Epub 2022 Nov 24.

Addressing sex-based disparities in liver transplantation

Melanie A Hundt  1   2 , Christine Tien  2 , Jeffrey A Kahn  1   2
Affiliations
Review

Addressing sex-based disparities in liver transplantation

Melanie A Hundt et al. Curr Opin Organ Transplant. .

Abstract

Purpose of review: Disparities in access to liver transplantation by sex have been well described, disadvantaging women. Understanding the multifactorial causes of these disparities as well as the variety of proposed solutions is critical to improving access to this life-saving intervention for women. This review aims to summarize the current body of evidence on observed sex disparities in liver transplantation and highlight actionable, evidence-based mechanisms by which these disparities can be addressed.

Recent findings: Strategies for addressing sex disparities in liver transplantation include increasing organ utilization, changing allocation policy, and leveraging public policies to reduce the incidence of end-stage liver disease. Several other promising interventions are currently being explored.

Summary: In the United States, women face additional barriers to liver transplantation on the basis of sex. Immediate action is necessary to systematically address these inequities.

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References

    1. Fast Stats - Chronic Liver Disease and Cirrhosis [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; 2022. Available at: https://www.cdc.gov/nchs/fastats/liver-disease.htm . [Accessed October 14, 2022].
    1. Moon AM, Singal AG, Tapper EB. Contemporary epidemiology of chronic liver disease and cirrhosis. Clin Gastroenterol Hepatol 2020; 18:2650–2666.
    1. Centers for Disease Control and Prevention, National Center for Health Statistics. National Vital Statistics System, Mortality 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Available at: http://wonder.cdc.gov/ucd-icd10.html . [Accessed 14 October 2022]
    1. Kwong AJ, Ebel NH, Kim WR, et al. OPTN/SRTR 2020 annual data report: liver. Am J Transplant 2022; 22 (S2):204–309.
    1. Allen AM, Heimbach JK, Larson JJ, et al. Reduced access to liver transplantation in women: role of height, MELD exception scores and renal function underestimation. Transplantation 2018; 102:1710–1716.