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. 2022 Nov 10:14:1003896.
doi: 10.3389/fnagi.2022.1003896. eCollection 2022.

Association of walking speed with cognitive function in Chinese older adults: A nationally representative cohort study

Jianping Liu  1 , Kaiwang Cui  1 , Qian Chen  1 , Zhiteng Li  1 , Jing Fu  1 , Xiangwen Gong  1 , Hui Xu  2
Affiliations

Association of walking speed with cognitive function in Chinese older adults: A nationally representative cohort study

Jianping Liu et al. Front Aging Neurosci. .

Abstract

Background: Slow walking speed has been shown to predict cognitive decline in older individuals, but studies conducted among Chinese older adults are scarce. We examined the association of walking speed with cognitive function and the trajectory of cognitive decline among Chinese adults aged 60 years and older.

Methods: Data was from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing nationally representative prospective cohort study. Walking speed was evaluated over a straight 2.5-meter flat course at baseline and categorized into tertiles (the lowest, middle, and highest). Cognitive function was assessed at each wave in three domains: episodic memory, mental status, and global cognition. Data were analyzed using linear mixed-effects models.

Results: A total of 3,954 older adults (48.6% female; mean age: 67.6 ± 5.55 years) were followed for up to 7 years. Participants with lowest walking speed have poorer episodic memory (β = -0.37; 95% CI: -0.46, -0.28), mental status (β = -0.45; 95% CI: -0.60, -0.29), and global cognition (β = -0.81; 95% CI: -1.03, -0.60) over the follow-up. Compared with the highest tertile of walking speed, the lowest walking speed was associated with a faster decline in episodic memory (β = -0.04; 95% CI: -0.07, -0.02), mental status (β = -0.04; 95% CI: -0.07, -0.01), and global cognition (β = -0.06; 95% CI: -0.11, -0.01).

Conclusion: Slower walking speed is associated with subsequent risk of poorer cognitive function and faster cognitive decline in older Chinese adults.

Keywords: cognitive function; cohort study; national; older Chinese adults; walking speed.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Average annual changes in cognitive function according to tertiles of walking speed. (A) Episodic memory; (B) mental status; (C) global cognition. Models were adjusted for age, sex, education, BMI, smoking, alcohol consumption, hypertension, diabetes, stroke, heart disease, lung disease, and follow-up time.
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