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. 2022 Oct 25;4(1):vdac171.
doi: 10.1093/noajnl/vdac171. eCollection 2022 Jan-Dec.

A scoping review of pediatric microdialysis: A missed opportunity for microdialysis in the pediatric neuro-oncology setting

Mahalia R Dalmage  1 , Anthony Nwankwo  1 , Hannah Sur  1 , Edjah Nduom  1   2 , Sadhana Jackson  1
Affiliations

A scoping review of pediatric microdialysis: A missed opportunity for microdialysis in the pediatric neuro-oncology setting

Mahalia R Dalmage et al. Neurooncol Adv. .

Abstract

Background: Brain microdialysis is a minimally invasive technique for monitoring analytes, metabolites, drugs, neurotransmitters, and/or cytokines. Studies to date have centered on adults with traumatic brain injury, with a limited number of pediatric studies performed. This scoping review details past use of brain microdialysis in children and identifies potential use for future neuro-oncology trials.

Methods: In December 2020, Cochrane Library: CENTRAL, Embase, PubMed, Scopus, and Web of Science: Core Collection were searched. Two reviewers screened all articles by title and abstract review and then full study texts, using microdialysis in patients less than 18 yo.

Results: Of the 1171 articles screened, 49 were included. The 49 studies included 472 pediatric patients (age range 0-17 years old), in the brain (21), abdominal (16), and musculoskeletal (12) regions. Intracerebral microdialysis was performed in 64 collective patients, with a median age of 11 years old, and predominance in metabolic evaluations.

Conclusion: Historically, pediatric microdialysis was safely performed within the brain in varied neurologic conditions, except neuro-oncology. Adult brain tumor studies using intratumoral/peritumoral microdialysis sampling can inform future pediatric studies to advance diagnosis and treatment options for such aggressive tumors.

Keywords: brain tumor; cancer; intracerebral monitoring; microdialysis; pediatric; pharmacokinetics.

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Figures

Figure 1.
Figure 1.
Modern intratumoral microdialysis technique depiction. The diagram demonstrates the intracerebral microdialysis tool sampling tumoral tissue pre or post-surgical intervention. The continuous infusion pump holds dialysate fluid to allow for automated infusion akin to passive diffusion (A). The semipermeable microdialysis catheter is placed within tumor tissue (B), while the microvial continuously collects brain interstitial fluid for further solute processing and measurements (C).
Figure 2.
Figure 2.
Microdialysis recovery equation detailing extraction efficiency through a semipermeable membrane.
See this image and copyright information in PMC

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