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. 2022 Nov;38(6):683-690.
doi: 10.6515/ACS.202211_38(6).20220424A.

Non-Alcoholic Fatty Pancreas Disease is Associated with SYNTAX Score in Acute Coronary Syndrome

Sinan Sahin  1 , M Gokhan Yerlikaya  1 , Ahmet Ozderya  1 , I Gokhan Cavusoglu  2 , Aysegul Karadeniz  2 , Turhan Turan  1 , Omer Faruk Cirakoglu  1 , Huseyin Karal  1 , Ali Riza Akyuz  1 , Selim Kul  1 , M Rasit Sayin  1
Affiliations

Non-Alcoholic Fatty Pancreas Disease is Associated with SYNTAX Score in Acute Coronary Syndrome

Sinan Sahin et al. Acta Cardiol Sin. 2022 Nov.

Abstract

Background: Evidence that individuals with excess fat in the pancreas have an increased risk of cardiovascular disease has been growing recently. Risk evaluation in acute coronary syndrome (ACS) patients plays a crucial role for both prognosis prediction and decision-making.

Aim: The main aim of this study was to investigate the relationship between non-alcoholic fatty pancreas disease (NAFPD) and the complexity and severity of coronary artery disease as assessed using the SYNTAX score (SXscore) in ACS patients.

Methods: A total of 99 consecutive patients with a first-time diagnosis of ACS were recruited. NAFPD was evaluated using transabdominal ultrasonography (TUS). SXscore was calculated using the SXscore algorithm.

Results: The patients with NAFPD had a significantly higher SXscore than those without NAFPD (12.3 ± 6.4 and 8.2 ± 4.3, p < 0.001). Univariable analysis showed that hypertension (p = 0.033) and presence of NAFPD (p = 0.001) were associated with increased SXscore. Moreover, multivariable analysis showed that the presence of NAFPD (p = 0.002) was associated with increased SXscore.

Conclusions: NAFPD is easily detected by TUS. The presence of NAFPD in ACS patients may be a warning signal of complexity and severity of coronary artery disease.

Keywords: Acute coronary syndrome; Atherosclerosis; Ectopic adipose tissue; Non-alcoholic fatty pancreas disease; SYNTAX score.

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Figures

Figure 1
Figure 1
(A) Arrow shows NAFPD. (B) Arrow shows normal pancreas. NAFPD, non-alcoholic fatty pancreas disease.
Figure 2
Figure 2
SXscore, with and without NAFPD subjects. NAFPD, non-alcoholic fatty pancreas disease; SXscore, Syntax score.
See this image and copyright information in PMC

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