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Review
. 2023 May;64(3):229-237.
doi: 10.1080/03008207.2022.2149397. Epub 2022 Nov 28.

Formyl peptide receptors in bone research

Mark A Lantieri  1 , Jose R Perdomo Trejo  1 , Quang Le  1 , Abhijit Dighe  1 , Quanjun Cui  1 , Xinlin Yang  1
Affiliations
Review

Formyl peptide receptors in bone research

Mark A Lantieri et al. Connect Tissue Res. 2023 May.

Abstract

Purpose/aim of the study: The formyl peptide receptor (FPR) participates in the immune response, with roles in infection and inflammation. In this review article, we summarize the current literature on these roles before discussing the function of FPRs in the pathogenesis of musculoskeletal disorders including osteoarthritis (OA), degenerative disc disease (DDD), and rheumatoid arthritis (RA). Additionally, we discuss the potential diagnostic and therapeutic roles of FPRs in these domains.

Methods: PubMed and Ovid MEDLINE searches were performed from 1965 through March 2022. Keywords included "FPR, tissue expression, inflammation, infection, musculoskeletal disorder, bone, rheumatoid arthritis, osteoarthritis, degenerative disc disease, mitochondria."

Results: Sixty-nine studies were included in this review article. FPRs appear to be ubiquitous in the pathogenesis, diagnosis, and treatment of common musculoskeletal disorders. They can potentially be utilized for the earlier diagnosis of OA and DDD. They may be employed with mesenchymal stem cells (MSCs) to reverse OA and DDD pathologies. With anti-inflammatory, anti-osteolytic, and pro-angiogenic functions, they may broaden treatment options in RA.

Conclusions: FPRs appear to be heavily involved in the pathogenesis of common musculoskeletal conditions, including arthritis, degenerative disc disease, and rheumatoid arthritis. Furthermore, they demonstrate much promise in the diagnosis and treatment of these conditions. Their roles should continue to be explored.

Keywords: Formyl peptide receptor; bone; infection; inflammation; musculoskeletal.

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Conflict of interest statement

Declaration of Interests

The authors report no conflict of interest.

Figures

Figure 1:
Figure 1:. Select roles of formyl peptide receptors (FPRs) in the pathogenesis and diagnosis and treatment of many common musculoskeletal diseases.
A1: role of FPRs in arthritis pathogenesis. A2: role of FPRs in arthritis diagnosis and treatment. B1: role of FPRs in degenerative disc disease (DDD) diagnosis and treatment. C1: role of FPRs in rheumatoid arthritis (RA) pathogenesis. C2: role of FPRs in RA diagnosis and treatment.
See this image and copyright information in PMC

References

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