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Review
. 2023 Jan;30(4):9082-9102.
doi: 10.1007/s11356-022-24361-2. Epub 2022 Nov 28.

Disturbance of cellular calcium homeostasis plays a pivotal role in glyphosate-based herbicide-induced oxidative stress

Diovana Gelati de Batista  1   2   3   4 , Edivania Gelati de Batista  5 , Antônio Azambuja Miragem  5 , Mirna Stela Ludwig  6   7 , Thiago Gomes Heck  6   7   8
Affiliations
Review

Disturbance of cellular calcium homeostasis plays a pivotal role in glyphosate-based herbicide-induced oxidative stress

Diovana Gelati de Batista et al. Environ Sci Pollut Res Int. 2023 Jan.

Abstract

Glyphosate-based herbicides (GBHs) are the most worldwide used pesticides. The wide application of GBHs contaminates the soil and, consequently, water and food resources reaching human consumption. GBHs induce oxidative stress in non-target organisms, leading to a pro-inflammatory and pro-apoptotic cellular status, promoting tissue dysfunction and, thus, metabolic and neurobehavioral changes. This review presents evidence of oxidative damage induced by GBHs and the mechanism of cell damage and health consequences. To summarize, exposure to GBHs may induce disorders in calcium homeostasis related to the activation of ion channels. Also, alterations in pathways related to redox state regulation must have a primordial role in oxidative stress caused by GBHs.

Keywords: Calcium; Cell death; Glyphosate; Inflammation; Pesticide; Reactive oxygen species; Toxicity.

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