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Review
. 2023 Jun;16(3):682-697.
doi: 10.1007/s12265-022-10342-w. Epub 2022 Nov 28.

The Effect of Extracellular Vesicles on Thrombosis

Youfu He  1   2   3 , Qiang Wu  4   5
Affiliations
Review

The Effect of Extracellular Vesicles on Thrombosis

Youfu He et al. J Cardiovasc Transl Res. 2023 Jun.

Abstract

The risk of cardiovascular events caused by acute thrombosis is high, including acute myocardial infarction, acute stroke, acute pulmonary embolism, and deep vein thrombosis. In this review, we summarize the roles of extracellular vesicles of different cellular origins in various cardiovascular events associated with acute thrombosis, as described in the current literature, to facilitate the future development of a precise therapy for thrombosis caused by such vesicles. We hope that our review will indicate a new horizon in the field of cardiovascular research with regard to the treatment of acute thrombosis, especially targeting thrombosis caused by extracellular vesicles secreted by individual cells. As more emerging technologies are being developed, new diagnostic and therapeutic strategies related to EVs are expected to be identified for related diseases in the future.

Keywords: Acute thrombosis; Endothelial cells; Extracellular vesicles; Inflammation; Tumor-secreted tissue factor.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Platelet activation and the release of extracellular vesicles
Fig. 2
Fig. 2
Extracellular vesicle entry and exit processes
Fig. 3
Fig. 3
Diagram illustrating the mechanism of blood coagulation caused by extracellular vesicles through various substances
See this image and copyright information in PMC

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