Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar;54(1):279-284.
doi: 10.1007/s42770-022-00858-3. Epub 2022 Nov 28.

Serological evidence of arenavirus circulation in wild rodents from central-west, southeast, and south regions of Brazil, 2002-2006

Ana Lúcia Rodrigues de Oliveira  1   2 , Mariana Sequetin Cunha  3 , Ivani Bisordi  4 , Renato Pereira de Souza  4 , Maria do Carmo Sampaio Tavares Timenetsky  5   6
Affiliations

Serological evidence of arenavirus circulation in wild rodents from central-west, southeast, and south regions of Brazil, 2002-2006

Ana Lúcia Rodrigues de Oliveira et al. Braz J Microbiol. 2023 Mar.

Abstract

Viral hemorrhagic fevers caused by arenaviruses are severe zoonotic diseases. In reservoirs, the presence of antibodies may indicate viral circulation in a population of a specific region, and these data can be used as an indicator for further investigations by molecular techniques. The present study aimed to detect the presence of arenavirus antibodies in wild rodents captured from 1998 to 2008 during epidemiological surveillance activities. A retrospective analysis of 2243 wild rodent blood samples using a broad cross-reactive in-house developed enzyme-linked immunosorbent assay (ELISA) revealed a 0.44% (10/2243) positive rate in wild rodents, which included Necromys lasiurus (6/1012), Calomys callosus (2/94), and Akodon sp. (2/273) species. These rodents were captured between 2002 to 2006 in Campo Alegre de Goiás/GO, Bodoquena/MS, Nuporanga/SP, and Mogi das Cruzes/SP. Our findings suggest the sylvatic circulation of arenavirus among wild rodents in the southeast region of Brazil. However, future virological and molecular studies are necessary to confirm the viral presence in these regions.

Keywords: ELISA; New World arenaviruses; Rodent-borne disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Locations where wild rodent species with the presence of IgG anti-Mammarenavirus antibodies were captured (2002–2006). Legend: Map of Brazil using Mapbiomas plug in (mapbiomas.org) showing vegetation coverage in 2006. Green areas refer to forest, yellow areas refer to crop, and blue areas refer to rivers. Red dots indicate cities where positive samples from wild rodents were captured in the States of Goiás (GO) and São Paulo (SP). Landscapes show locations where IgG-positive rodents were captured. Nuporanga/SP; Mogi das Cruzes/SP; Campo Alegre de Goiás/GO, Bodoquena (MS)*. Maps were generated using QGIS software version 3.16 Hannover. *no coordinates were obtained from these cases; only farm address was available in the record
See this image and copyright information in PMC

References

    1. Radoshitzky SR, Buchmeier MJ, Charrel RN, et al. ICTV virus taxonomy profile: Arenaviridae. J Gen Virol. 2019;100:1200–1201. doi: 10.1099/jgv.0.001280. - DOI - PMC - PubMed
    1. Radoshitzky SR, Bào Y, Buchmeier MJ, et al. Past, present, and future of arenavirus taxonomy. Arch Virol. 2015;160:1851–1874. doi: 10.1007/s00705-015-2418-y. - DOI - PubMed
    1. Shao J, Liang Y, Ly H. Human hemorrhagic fever causing arenaviruses: molecular mechanisms contributing to virus virulence and disease pathogenesis. Pathog (Basel, Switzerland) 2015;4:283–306. doi: 10.3390/pathogens4020283. - DOI - PMC - PubMed
    1. Buchmeier M, Peters CJ, De la Torre C. Arenaviridae: the virus and their replication. Fields Virol. 2007;2:1792–1827.
    1. Charrel RN, de Lamballerie X. Zoonotic aspects of arenavirus infections. Vet Microbiol. 2010;140:213–220. doi: 10.1016/j.vetmic.2009.08.027. - DOI - PubMed

Substances

LinkOut - more resources