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. 1978 Nov;5(11):4215-23.
doi: 10.1093/nar/5.11.4215.

Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine

S Noguchi, Z Yamaizumi, T Ohgi, T Goto, Y Nishimura, Y Hirota, S Nishimura
Free PMC article

Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine

S Noguchi et al. Nucleic Acids Res. 1978 Nov.
Free PMC article

Abstract

One of the E. coli mutants selected for deficiency of modified nucleoside Q was found to contain an analogue of Q and normal guanosine in place of Q. The analogue of Q, designated as preQo, was isolated on a large scale from purified tRNATyr containing preQo. The structure of preQo was determined to be 7-(cyano)-7-deazaguanosine by comparison of its ultraviolet absorption spectra, thin-layer chromatographic mobility and mass spectrum with those of synthetic material.

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