Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review

doi:10.1002/pca.3187

Review

. 2023 Jan;34(1):5-29.

doi: 10.1002/pca.3187. Epub 2022 Nov 28.

Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review

Hongmin Xia^{1

2}, Yanpeng Dai², Chengxin Zhao³, Huimin Zhang², Yusheng Shi^{4

5

6}, Hongxiang Lou¹

Affiliations

¹ School of Pharmaceutical Sciences, Shandong University, Jinan, China.
² Key Disciplines on Analysis of Traditional Chinese Medicine of SATCM, the Key Unit for Research of Technique and Principle of Honey-Processing and Carbonizing of SATCM, Shandong Key Laboratory of Chinese Medicine Quality Standard Research, Taishan Scholar-Distinguished Experts Position, Shandong Academy of Chinese Medicine, Jinan, China.
³ The People's Republic of China Taian Customs, Taian, China.
⁴ Key Laboratory of Biotechnology and Bioresources Utilization, Educational of Minister, College of Life Science, Dalian Nationalities University, Dalian, China.
⁵ National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, China.
⁶ Academy of Integrative Medicine, Dalian Medical University, Dalian, China.

PMID: 36442477
DOI: 10.1002/pca.3187

Review

Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review

Hongmin Xia et al. Phytochem Anal. 2023 Jan.

. 2023 Jan;34(1):5-29.

doi: 10.1002/pca.3187. Epub 2022 Nov 28.

Authors

Hongmin Xia^{1

2}, Yanpeng Dai², Chengxin Zhao³, Huimin Zhang², Yusheng Shi^{4

5

6}, Hongxiang Lou¹

Affiliations

¹ School of Pharmaceutical Sciences, Shandong University, Jinan, China.
² Key Disciplines on Analysis of Traditional Chinese Medicine of SATCM, the Key Unit for Research of Technique and Principle of Honey-Processing and Carbonizing of SATCM, Shandong Key Laboratory of Chinese Medicine Quality Standard Research, Taishan Scholar-Distinguished Experts Position, Shandong Academy of Chinese Medicine, Jinan, China.
³ The People's Republic of China Taian Customs, Taian, China.
⁴ Key Laboratory of Biotechnology and Bioresources Utilization, Educational of Minister, College of Life Science, Dalian Nationalities University, Dalian, China.
⁵ National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, China.
⁶ Academy of Integrative Medicine, Dalian Medical University, Dalian, China.

PMID: 36442477
DOI: 10.1002/pca.3187

Abstract

Introduction: Euodiae fructus, also known as Evodiae fructus, is a popular Chinese herbal medicine derived from the dried, nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley. The main bioactive constituents of Euodiae fructus are alkaloids, limonoids, flavonoids, and anthraquinones. The contents of these compounds vary greatly between different plant species, geographic locations, and harvest times, which thus affect the therapeutic effects.

Objectives: We aimed to summarize the chromatographic and mass spectrometric technologies applied for chemical analysis and quality evaluation of Euodiae fructus. Moreover, we aimed to emphasize the diverse soft ionization techniques and mass analyzers of LC-MS methods for assessment of Euodiae fructus.

Methodology: A literature study was carried out by retrieving articles published between January 1988 and December 2021 from well-known databases, including PubMed, ASC, Elsevier, ScienceDirect, J·STAGE, Thieme, Taylor & Francis, Springer Link, Wiley Online Library, and CNKI. The chemical analysis methods were described in several categories in accordance with the used analytical techniques, including thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), high-performance liquid chromatography-mass spectrometry (HPLC-MS), gas chromatography-mass spectrometry (GC-MS), capillary electrophoresis (CE), and counter-current chromatography (CCC).

Results: This review systematically summarizes the achievements in chemical analysis and quality evaluation of Euodiae fructus published in over three decades, covering the various chromatographic and mass spectrometric technologies applied for identification and quantification of phytochemical constituents.

Conclusion: The summary serves as an important basis for future phytochemical research and implementation of quality control methods in order to ensure the efficacy and safety of Euodiae fructus.

Keywords: Euodiae fructus; Evodiae fructus; Tetradium ruticarpum; chromatography; mass spectrometry.

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References

REFERENCES

1. European Pharmacopoeia Commission. European Pharmacopoeia 11.0 Edition. European Directorate for the Quality of Medicines & HealthCare of the Council of Europe. 2022;1506-1508.
1. Li ML, Wang CH. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: a review. J Ethnopharmacol. 2020;263:113231 doi:10.1016/j.jep.2020.113231
1. Chinese Pharmacopeia Commission. Pharmacopeia of People's Republic of China, vol. 1. Beijing: China Medical Science Press; 2020:178-179.
1. Zhao ZF, He XR, Han W, et al. Genus Tetradium L.: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2019;231:337-354.
1. Zhou X, Yang Z, Lei PH, Cai ZW, Liu H. Chromatographic fingerprint study on Evodia rutaecarpa (Juss.) Benth by HPLC/DAD/ESI-MSn technique. J Sep Sci. 2010;33(15):2258-2265. doi:10.1002/jssc.201000035

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[1] European Pharmacopoeia Commission. European Pharmacopoeia 11.0 Edition. European Directorate for the Quality of Medicines & HealthCare of the Council of Europe. 2022;1506-1508.

[2] European Pharmacopoeia Commission. European Pharmacopoeia 11.0 Edition. European Directorate for the Quality of Medicines & HealthCare of the Council of Europe. 2022;1506-1508.

[3] Li ML, Wang CH. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: a review. J Ethnopharmacol. 2020;263:113231 doi:10.1016/j.jep.2020.113231

[4] Li ML, Wang CH. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: a review. J Ethnopharmacol. 2020;263:113231 doi:10.1016/j.jep.2020.113231

[5] Chinese Pharmacopeia Commission. Pharmacopeia of People's Republic of China, vol. 1. Beijing: China Medical Science Press; 2020:178-179.

[6] Chinese Pharmacopeia Commission. Pharmacopeia of People's Republic of China, vol. 1. Beijing: China Medical Science Press; 2020:178-179.

[7] Zhao ZF, He XR, Han W, et al. Genus Tetradium L.: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2019;231:337-354.

[8] Zhao ZF, He XR, Han W, et al. Genus Tetradium L.: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2019;231:337-354.

[9] Zhou X, Yang Z, Lei PH, Cai ZW, Liu H. Chromatographic fingerprint study on Evodia rutaecarpa (Juss.) Benth by HPLC/DAD/ESI-MSn technique. J Sep Sci. 2010;33(15):2258-2265. doi:10.1002/jssc.201000035

[10] Zhou X, Yang Z, Lei PH, Cai ZW, Liu H. Chromatographic fingerprint study on Evodia rutaecarpa (Juss.) Benth by HPLC/DAD/ESI-MSn technique. J Sep Sci. 2010;33(15):2258-2265. doi:10.1002/jssc.201000035

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Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review

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Chromatographic and mass spectrometric technologies for chemical analysis of Euodiae fructus: A review

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