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. 2022 Nov 29;8(1):127.
doi: 10.1038/s41421-022-00493-0.

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6

Aiste Dijokaite-Guraliuc #  1 , Raksha Das #  1 , Rungtiwa Nutalai  1 , Daming Zhou  2   3 , Alexander J Mentzer  1   4 , Chang Liu  1   3 , Piyada Supasa  1 , Susanna J Dunachie  4   5   6   7 , Teresa Lambe  3   8 , Elizabeth E Fry  2 , Juthathip Mongkolsapaya  1   3 , Jingshan Ren  2 , Jiandong Huo  9   10 , David I Stuart  11   12   13 , Gavin R Screaton  14   15
Affiliations

Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6

Aiste Dijokaite-Guraliuc et al. Cell Discov. .
No abstract available

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Conflict of interest statement

G.R.S. sits on the GSK Vaccines Scientific Advisory Board, is a consultant to Astra Zeneca, and is a founder member of RQ Biotechnology. Oxford University holds intellectual property related to the Oxford-Astra Zeneca vaccine and SARS-CoV-2 mAb discovered in G.R.S’s laboratory. T.L. is named as an inventor on a patent application covering this SARS-CoV-2 vaccine and was a consultant to Vaccitech for an unrelated project whilst the study was conducted. S.J.D. is a Scientific Advisor to the Scottish Parliament on COVID-19.

Figures

Fig. 1
Fig. 1. Characterisation of BA.4.6 by pseudoviral neutralization assay.
a–d Pseudoviral neutralization assays of BA.4.6 by vaccine, BA.1, BA.2, and BA.4.5 immune serum. IC50 values for the indicated viruses using serum obtained from vaccinees 28 days following their third dose of Pfizer BNT162b2 vaccine (n = 22, a). IC50 values for the indicated viruses against serum from volunteers suffering vaccine breakthrough BA.1 (n = 14, b), BA.2 (n = 23, c) and BA.4/5 (n = 11, d) infections. Geometric mean titers are shown above each column. The Wilcoxon matched-pairs signed rank test was used for the analysis and two-tailed P values were calculated. e Neutralization curves for a panel of 28 monoclonal antibodies made from samples taken from vaccinees infected with BA.1 against BA.4.6 were compared with Victoria, BA.1, BA.1.1, BA.2, BA.4/5, and BA.2.75 variants. Error bars represent means ± SEM of repeat experiments. f Neutralization curves for a panel of 12 commercial monoclonal antibodies against same variants. IC50 ± SEM values are shown in Supplementary Table S2.
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References

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