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Meta-Analysis
. 2023 Feb;24(2):e13534.
doi: 10.1111/obr.13534. Epub 2022 Nov 28.

Deciphering the "obesity paradox" in the elderly: A systematic review and meta-analysis of sarcopenic obesity

Chaoran Liu  1 , Pui Yan Wong  1 , Yik Lok Chung  1 , Simon Kwoon-Ho Chow  1 , Wing Hoi Cheung  1 , Sheung Wai Law  1 , Juliana Chung Ngor Chan  2 , Ronald Man Yeung Wong  1
Affiliations
Meta-Analysis

Deciphering the "obesity paradox" in the elderly: A systematic review and meta-analysis of sarcopenic obesity

Chaoran Liu et al. Obes Rev. 2023 Feb.

Abstract

Aging and obesity are two global concerns in public health. Sarcopenic obesity (SO), defined as the combination of age-related sarcopenia and obesity, has become a pressing issue. This systematic review and meta-analysis summarize the current clinical evidence relevant to SO. PubMed, Embase, and Web of Science were searched, and 106 clinical studies with 167,151 elderlies were included. The estimated prevalence of SO was 9% in both men and women. Obesity was associated with 34% reduced risk of sarcopenia (odds ratio [OR] 0.66, 95% CI 0.48-0.91; p < 0.001). The pooled hazard ratio (HR) of all-cause mortality was 1.51 (95% CI 1.14-2.02; p < 0.001) for people with SO compared with healthy individuals. SO was associated with increased risk of cardiovascular disease and related mortality, metabolic disorders, cognitive impairment, arthritis, functional limitation, and lung diseases (all ORs > 1.0, p < 0.05). The attenuated risk of sarcopenia in elderlies with obesity ("obesity paradox") was dependent on higher muscle mass and strength. Apart from unifying the diagnosis of SO, more research is needed to subphenotype people with obesity and sarcopenia for individualized treatment. Meanwhile, the maintenance of proper body composition of muscle and fat may delay or attenuate the adverse outcomes of aging.

Keywords: adipose; aging; muscle; sarcopenic obesity.

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References

REFERENCES

    1. Tam BT, Morais JA, Santosa S. Obesity and ageing: two sides of the same coin. Obes Rev. 2020;21:e12991.
    1. Mathus-Vliegen EM. Prevalence, pathophysiology, health consequences and treatment options of obesity in the elderly: a guideline. Obes Facts. 2012;5:460-483.
    1. Wang L, Zhou B, Zhao Z, et al. Body-mass index and obesity in urban and rural China: findings from consecutive nationally representative surveys during 2004-18. Lancet. 2021;398:53-63.
    1. Arner P, Bernard S, Appelsved L, et al. Adipose lipid turnover and long-term changes in body weight. Nat Med. 2019;25:1385-1389.
    1. Ahn H, Kim DW, Ko Y, et al. Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: a new paradigm beyond sarcopenia. Ageing Res Rev. 2021;101398. doi:10.1016/j.arr.2021.101398

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