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. 2022 Nov 15;4(4):474-487.
doi: 10.1016/j.jaccao.2022.08.011. eCollection 2022 Nov.

Outcomes by Cardiac Stage in Patients With Newly Diagnosed AL Amyloidosis: Phase 3 ANDROMEDA Trial

Monique C Minnema  1 , Angela Dispenzieri  2 , Giampaolo Merlini  3   4 , Raymond L Comenzo  5 , Efstathios Kastritis  6 , Ashutosh D Wechalekar  7 , Martha Grogan  2 , Ronald Witteles  8 , Frederick L Ruberg  9 , Mathew S Maurer  10 , NamPhuong Tran  11 , Xiang Qin  12 , Sandra Y Vasey  12 , Brendan M Weiss  12 , Jessica Vermeulen  13 , Arnaud Jaccard  14
Affiliations

Outcomes by Cardiac Stage in Patients With Newly Diagnosed AL Amyloidosis: Phase 3 ANDROMEDA Trial

Monique C Minnema et al. JACC CardioOncol. .

Abstract

Background: Patients with amyloid light chain amyloidosis and severe cardiac dysfunction have a poor prognosis. Treatment options that induce rapid and deep hematologic and organ responses, irrespective of cardiac involvement, are needed.

Objectives: The aim of this study was to evaluate the impact of baseline cardiac stage on efficacy and safety outcomes in the phase 3 ANDROMEDA trial.

Methods: Rates of overall complete hematologic response and cardiac and renal response at 6 months and median major organ deterioration-progression-free survival and major organ deterioration-event-free survival were compared across cardiac stages (I, II, or IIIA) and treatments (daratumumab, bortezomib, cyclophosphamide, and dexamethasone [D-VCd] or bortezomib, cyclophosphamide, and dexamethasone [VCd]). Rates of adverse events (AEs) were summarized for patients with and without baseline cardiac involvement and by cardiac stage.

Results: Median follow-up duration was 15.7 months. The proportions of stage I, II, and IIIA patients were 23.2%, 40.2%, and 36.6%. Across cardiac stages, hematologic and organ response rates were higher and major organ deterioration-progression-free survival and major organ deterioration-event-free survival were longer with D-VCd than VCd. AE rates were similar between treatments and by cardiac stage; serious AE rates were higher in patients with cardiac involvement and increased with increasing cardiac stage. The incidence of cardiac events was numerically greater with D-VCd vs VCd, but the rate of grade 3 or 4 events was similar. The exposure-adjusted incidence rate for cardiac events was lower with D-VCd than VCd (median exposure 13.4 and 5.3 months, respectively).

Conclusions: These findings demonstrate the efficacy of D-VCd over VCd in patients with newly diagnosed amyloid light chain amyloidosis across cardiac stages, thus supporting its use in patients with cardiac involvement. (NCT03201965).

Keywords: AE, adverse event; AL, amyloid light chain; CR, complete response; D-VCd, daratumumab, bortezomib, cyclophosphamide, and dexamethasone; EFS, event-free survival; FLC, free light chain; Mayo staging system; NT-proBNP, N-terminal pro–brain natriuretic peptide; NYHA, New York Heart Association; PFS, progression-free survival; SAE, serious adverse event; VCd, bortezomib, cyclophosphamide, and dexamethasone; daratumumab; hs-cTnT, high-sensitivity cardiac troponin T.

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Conflict of interest statement

This research was funded by Janssen Research & Development. Prof Minnema has consulted or served in an advisory role for Janssen-Cilag, Alnylam, and Gilead; has served on a Speakers Bureau for Bristol Myers Squibb; and has received travel, accommodation, and expense compensation from Celgene. Dr Dispenzieri has received research funding from Alnylam, Celgene, Intellia, Janssen, Pfizer, and Takeda. Dr Comenzo has consulted or served in an advisory role for Amgen, Caelum, Janssen, Karyopharm, Prothena, Sanofi, Takeda, and Unum; and has received research funding from Janssen, Karyopharm, Prothena, and Takeda. Dr Kastritis has consulted or served in an advisory role for and has received honoraria from Amgen, Genesis Pharma, Janssen, Pfizer, and Takeda; and has received research funding from Amgen and Janssen. Prof Wechalekar has consulted or served in an advisory role for Caelum and Janssen; has received honoraria from Celgene, Janssen, and Takeda; and has received travel, accommodation, and expense compensation from Takeda. Dr Witteles has served in an advisory role for Alnylam Pharmaceuticals, Pfizer, Akcea/Ionis, Eidos, and Regeneron. Dr Ruberg has consulted for Attralus and Alexion; and has received research funding from Akcea, Alnylam, and Pfizer. Dr Maurer has consulted or served in an advisory role for Alnylam Pharmaceuticals and Pfizer; and has received research funding from Akcea, Alnylam Pharmaceuticals, Eidos, Ionis, Intellia, Novo Nordisk, and Pfizer. Prof Jaccard has consulted or served in an advisory role for Janssen; and has received honoraria, research funding, and travel, accommodation, and expense compensation from Celgene and Janssen. Dr Weiss was an employee of Janssen at the time the study was conducted. Dr Tran, Mr Qin, Ms Vasey, and Dr Vermeulen are employees of Janssen. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Hematologic CR, Cardiac Response, and Renal Response Irrespective of cardiac stage, rates of overall hematologic complete response (A), cardiac response (B), and renal response (C) at 6 months were higher with daratumumab, bortezomib, cyclophosphamide, and dexamethasone (D-VCd) than bortezomib, cyclophosphamide, and dexamethasone (VCd).
Figure 2
Figure 2
Major Organ Deterioration–PFS and Major Organ Deterioration–EFS Irrespective of cardiac stage, major organ deterioration–progression-free survival (PFS) (A) and major organ deterioration–event-free survival (EFS) (B) were longer with D-VCd than VCd. Abbreviations as in Figure 1.
Figure 3
Figure 3
NT-proBNP in ITT Analysis Set, Patients Evaluable for Cardiac Response, and Troponin Mean N-terminal pro–brain natriuretic peptide (NT-proBNP) in the ITT population (A) and in cardiac response-evaluable patients (B) and mean high-sensitivity troponin levels (C) decreased over time in both groups, suggesting no negative impact on cardiac function from the addition of daratumumab to VCd. Disease evaluations were conducted at the screening phase, during treatment cycles 1-6, and every 8 weeks until disease progression. Abbreviations as in Figure 1.
Central Illustration
Central Illustration
Select Clinical Outcomes by Baseline Cardiac Stage in the ANDROMEDA Study Rates of overall hematologic complete response and major organ deterioration–progression-free survival were improved with daratumumab, bortezomib, cyclophosphamide, and dexamethasone (D-VCd) compared with bortezomib, cyclophosphamide, and dexamethasone (VCd) in patients with newly diagnosed amyloid light chain amyloidosis.
See this image and copyright information in PMC

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