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. 2023 Mar;65(3):579-590.
doi: 10.1007/s00234-022-03086-6. Epub 2022 Nov 30.

Altered brain function in patients with vestibular migraine: a study on resting state functional connectivity

Zhengwei Chen  1 , Liangqun Rong  1 , Lijie Xiao  1 , Quan Wang  2 , Yueji Liu  1 , Cunxin Lin  1 , Jianing Wang  1 , Haiyan Liu  3 , Xiu-E Wei  4
Affiliations

Altered brain function in patients with vestibular migraine: a study on resting state functional connectivity

Zhengwei Chen et al. Neuroradiology. 2023 Mar.

Abstract

Purpose: To characterize the altered brain function in patients with vestibular migraine (VM) using resting-state functional magnetic resonance imaging (fMRI).

Methods: In this prospective study, fMRI images as well as clinical characteristics and behavioral scales were collected from 40 VM patients and 40 healthy controls (HC). All patients received neurological, neuro-otological, and conventional MRI examinations to exclude peripheral vestibular lesions, focal lesions, and other neurological diseases. Seed-based (bilateral parietal operculum cortex 2, OP2) functional connectivity (FC) and independent component analysis (ICA)-based functional network connectivity (FNC) were performed to investigate the brain functional changes in patients with VM. Additionally, the correlations between the altered FC/FNC and behavioral results were analyzed.

Results: Compared with HC, patients with VM showed increased FC between the left OP2 and right precuneus and exhibited decreased FC between the left OP2 and left anterior cingulate cortex. We also observed increased FC between the right OP2 and regions of the right middle frontal gyrus and bilateral precuneus, as well as decreased FC between the bilateral OP2. Furthermore, patients with VM showed decreased FNC between visual network (VN) and networks of auditory and default mode, and exhibited increased FNC between VN and executive control network. A correlation analysis found that FC between the left OP2 and right precuneus was positively correlated with scores of dizziness handicap inventory (DHI) in patients with VM.

Conclusion: The present study demonstrated altered brain function in patients with VM.

Keywords: Functional connectivity; Functional network connectivity; Independent component analysis; Migraine; Resting-state fMRI; Vestibular migraine.

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