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Review
. 2022 Oct 27;14(10):e30780.
doi: 10.7759/cureus.30780. eCollection 2022 Oct.

Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis

Mazin Alsarraj  1 , Sami M Alshehri  2 , Abdulrahman Qattan  2 , Abdelelah Mofti  3 , Lana Wazqer  2 , Sumayiah Bukhari  2 , Aisha Shamsaldin  2 , Rahaf Rajab  2
Affiliations
Review

Lymph Node Involvement and the Clinical Stage as Predictors of the Survival of Patients With Adenoid Cystic Carcinoma of the Head and Neck: A Systematic Review and Meta-Analysis

Mazin Alsarraj et al. Cureus. .

Abstract

In the treatment of various patients, the presence of lymphovascular invasion is a prognostic determinant, often taken into account by surgeons and oncologists. The exact frequency and prognostic impacts of this microscopic event in adenoid cystic carcinoma (ACC) patients are, however, not clear. This systematic review and meta-analysis aimed to investigate the lymph node involvement and the clinical stage of cancer as predictors of ACC prognosis. A systematic search was conducted covering a number of databases, including PubMed, Science Direct, Google Scholar, Web of Science, and EBSCO. A total of three studies were included in this analysis, with 591 participants, 247 of whom were males. Lymph node involvement and clinical stage were demonstrated as significant bad prognosis factors among ACC patients (HR = 1.48, 95% CI, 1.00, 1.96; P<0.0001). We found that lymph node involvement and clinical stage of the cancer are both significant predictors of bad prognosis of ACC.

Keywords: adenoid cystic carcinoma (acc); head and neck tumors; lymph node status; salivary gland tumor; stage.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart presenting a summary of the selection process
Figure 2
Figure 2. Forest plot of the effect of lymph node involvement and clinical stage of cancer on the development of adenoid cystic carcinoma
The red box represents the quantitative value of each entry. The black diamond symbol represents the pooled effect estimate with confidence intervals. Studies included [26,28,29].
Figure 3
Figure 3. Funnel plot of publication bias detection
Circles represent plotted data from each entry on the funnel plot.
See this image and copyright information in PMC

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