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. 2023 Mar 15;207(6):780-783.
doi: 10.1164/rccm.202207-1360LE.

Morphological Differences between Patient Self-inflicted and Ventilator-induced Lung Injury: An Experimental Study

Pablo Cruces  1   2 , Benjamín Erranz  3 , Carlos González  1 , Franco Diaz  2   4
Affiliations

Morphological Differences between Patient Self-inflicted and Ventilator-induced Lung Injury: An Experimental Study

Pablo Cruces et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Global and regional histological lung injury score. (B and C) Specific components of semiquantitative LIS. Representative images of lung histology for each study group (hematoxylin and eosin, 400×): (D, a) Image from the VILI group presented alveolar epithelial damage with atelectasis and areas of alveolar wall collapse with loss of air space. (D, b) Image from the P-SILI group presented hyperemia, perivascular edema, and hemorrhage. (D, c) Image from the Protective-MV group presented mild perivascular edema and alveolar wall rupture. (D, d) Image from Sham group presented normal lung sections. Data are expressed as median (interquartile range). Significant within-group differences are denoted by P < 0.05. BALT = bronchus-associated lymphoid tissue; MV = mechanical ventilation; P-SILI = patient self-inflicted lung injury; LIS = lung injury score; sLIS = semiquantitative lung injury score; VILI = ventilator-induced lung injury.
See this image and copyright information in PMC

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References

    1. Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir Crit Care Med . 2017;195:438–442. - PubMed
    1. Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury. Crit Care Med . 2013;41:536–545. - PubMed
    1. Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury. Crit Care Med . 2012;40:1578–1585. - PubMed
    1. Mascheroni D, Kolobow T, Fumagalli R, Moretti MP, Chen V, Buckhold D. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med . 1988;15:8–14. - PubMed
    1. Hurtado DE, Erranz B, Lillo F, Sarabia-Vallejos M, Iturrieta P, Morales F, et al. Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation. Ann Intensive Care . 2020;10:107. - PMC - PubMed

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