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Case Reports
. 2023 Jul 15;62(14):2103-2105.
doi: 10.2169/internalmedicine.0647-22. Epub 2022 Nov 30.

Fanconi Syndrome Associated with Long-term Treatment with Zoledronate

Rinko Katsunuma  1 , Kensuke Mitsumoto  1 , Aya Mizumoto  1 , Yuri Hirai  1 , Chiaki Nakauchi  2 , Takashi Uzu  1
Affiliations
Case Reports

Fanconi Syndrome Associated with Long-term Treatment with Zoledronate

Rinko Katsunuma et al. Intern Med. .

Abstract

Intravenous bisphosphonate therapy is used to prevent fractures in the management of bone metastasis. However, it may induce renal damage. We herein report an 81-year-old woman with Fanconi syndrome and osteomalacia who had been diagnosed with metastatic breast cancer and received treatment with zolendronate for over 5 years. Her bone markers normalized after switching zolendronate to denosmab and starting vitamin D and mineral supplementation. This case shows that chronic renal damage induced by zolendronate can cause osteomalacia. In patients with intravenous zolendronate therapy, close monitoring of renal and bone markers is needed, even under long-term therapy.

Keywords: bisphosphonate; hypokalemia; hypophosphatemia; metabolic acidosis; osteomalacia.

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Conflict of interest statement

Author's disclosure of potential Conflicts of Interest (COI).

Takashi Uzu: Honoraria, Eli Lilly Japan, AstraZeneca and Kyowa Kirin.

Comment in

References

    1. World Health Organization. Breast cancer [Internet]. [cited 2021 Mar 26]. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer
    1. Domchek SM, Younger J, Finkelstein DM, Seiden MV. Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89: 363-368, 2020. - PubMed
    1. Gennari A, André F, Barrios CH, et al. . ESMO clinical practice guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer. Ann Oncol 32: 1475-1495, 2021. - PubMed
    1. Gradishar WJ, Anderson BO, Agraham J, et al. . Breast cancer, ver 3.2020, NCCN clinical practice guideline in oncology. J Natl Compr Canc Netw 18: 452-478, 2020. - PubMed
    1. Coleman R, Camreon D, Dodwell D, et al. . Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial. Lancet Oncol 15: 997-1006, 2014. - PubMed

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