Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;65(7):942-952.
doi: 10.1111/dmcn.15467. Epub 2022 Nov 30.

Survival and long-term socioeconomic consequences of childhood and adolescent onset of brain tumours

Line Pickering  1 , Katharina M Main  2   3 , Ulla Feldt-Rasmussen  3   4 , Astrid Sehested  5 , René Mathiasen  5 , Marianne Klose  4 , Rikke Ibsen  6 , Jakob Kjellberg  7 , Poul Jennum  1   3
Affiliations
Free article

Survival and long-term socioeconomic consequences of childhood and adolescent onset of brain tumours

Line Pickering et al. Dev Med Child Neurol. 2023 Jul.
Free article

Abstract

Aim: To evaluate survival distributions, long-term socioeconomic consequences, and health care costs in patients with childhood and adolescent onset of brain tumours in a Danish nationwide prospective cohort study.

Method: A search of national registries identified 2283 patients (1198 males, 1085 females; mean age 9 years 6 months [SD 5 years 7 months]) diagnosed with a brain tumour between 1980 and 2015 and aged no older than 18 years at diagnosis. These were compared with sex-, age-, and residency-matched comparison individuals. Patients with malignant tumours were compared with those with benign tumours. Survival distributions were estimated by the Kaplan-Meier method and hazard ratio by the Cox proportional hazard model. Socioeconomic data at age 20 and 30 years were assessed.

Results: The probability of mortality was highest during the first year after tumour diagnosis. In young adulthood, the patients were generally less likely to be married, had lower grade-point averages, educational levels, and income, were less likely to be in employment, and had higher health care costs than comparison individuals. Patients with malignant tumours had worse outcomes with respect to education, employment, and health care costs than those with benign tumours.

Interpretation: A diagnosis of brain tumour in childhood and adolescence adversely affects survival and has negative long-term socioeconomic consequences, especially in patients with malignant tumours. These patients require continuous social support.

PubMed Disclaimer

Comment in

References

REFERENCES

    1. Vienneau D, Infanger D, Feychting M, et al. A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures: A validation of interview data. Cancer Epidemiol. 2016; 40: 52-59.
    1. Linet MS, Ries LA, Smith MA, Tarone RE, Devesa SS. Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States. J Natl Cancer Inst. 1999; 91(12): 1051-1058.
    1. Lannering B, Sandström P-E, Holm S, et al. Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005. Acta Paediatr. 2009; 98(10): 1620-1627.
    1. Patel V, McNinch NL, Rush S. Diagnostic delay and morbidity of central nervous system tumors in children and young adults: a pediatric hospital experience. J Neurooncol. 2019; 143(2):297-304.
    1. Larouche V, Toupin A-K, Lalonde B, Simonyan D, Jabado N, Perreault S. Incidence trends in pediatric central nervous system tumors in Canada: a 15 years report from Cancer and Young People in Canada (CYP-C) registry. Neuro-oncology Adv. 2020; 2(1): vdaa012.

Publication types

LinkOut - more resources