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. 2022 Nov 14:12:999203.
doi: 10.3389/fonc.2022.999203. eCollection 2022.

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

Qiuqiu Qiu  1 , Can Deng  1 , Hanqiang Li  1 , Junhui Qiu  1 , Zefeng Shen  2 , Yongquan Ding  1
Affiliations

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis

Qiuqiu Qiu et al. Front Oncol. .

Abstract

Intravesical instillation of Bacillus Calmette-Guérin has been used as an immunotherapy to treat superficial bladder cancer for almost half a century. In recent years, the approval of several monoclonal antibody treatments has transformed the treatment landscape for patients with muscle-invasive or metastatic uroepithelial carcinoma. The purpose of this study was to conduct a thorough review of immunotherapy in bladder cancer through a bibliometric approach. Publications related to bladder cancer immunotherapy were obtained from the Web of Science Core Collection on July 1st, 2022. We conducted a bibliometric analysis of literature information using CiteSpace IV, VOSviewer, and Scimago Graphica, including co-authorship or co-citation of authors, countries/regions, journals, references, and keyword co-occurrence. There was a total of 2,352 papers included, with the most contributions coming from the United States, China, and Italy. The United States had the highest H-index value and was the leading country in this field. Meanwhile, the number of publications in China was steadily growing. The top three productive researchers were Kamat AM, Necchi A, and Shariat SF, with Powles T as the top co-cited author. Most papers were published by the University of Texas System. The majority of papers in this field were published in Urologic Oncology Seminars and Original Investigations and European Urology was the most influential journal with the highest H-index. The tumor microenvironment and complete molecular characterization may still be the frontier in this research area, allowing us to obtain a better understanding of the pathogenesis and clinical prognosis of bladder cancer. More research are conducted to identify clinically meaningful biomarkers that may provide opportunities for the personalization of bladder cancer therapy. This study provides clinicians and researchers with an overview and helpful guidance on how to choose the research direction and management of bladder cancer immunotherapy.

Keywords: bibliometrics; bladder cancer; immune checkpoint inhibitor; immunotherapy; metastatic urothelial carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of search strategy in this study.
Figure 2
Figure 2
Publication outputs and growth forecast. (A) Number of published articles and citations on BC immunotherapy from 2012 to 2021. (B) Model-fitted curves of prediction of future publication in BC immunotherapy research.
Figure 3
Figure 3
(A) The changing trend of the annual publication quantity in the top 10 countries/regions from 2012 to 2021. (B) The international collaborations’visualization map of countries/regions.
Figure 4
Figure 4
The network map of cooperation between affiliations.
Figure 5
Figure 5
The dual-map overlay of journals.
Figure 6
Figure 6
Visualization map of co-authorship (A) and co-citation (B) analyses of authors generated by VOSviewer software.
Figure 7
Figure 7
The cluster view map (A) and timelines view map (B) of co-cited references analysis generated by CiteSpace software.
Figure 8
Figure 8
The network visualization map (A) and overlay visualization map (B) of the 114 phrases with at least 10 times frequency were created by VOSviewer. The more frequently the keywords appear, the larger the nodes is.
Figure 9
Figure 9
The top 25 keywords with the highest citation bursts in BC immunotherapy (generated by CiteSpace software).
See this image and copyright information in PMC

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