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Review
. 2022 Nov 28;14(11):e31973.
doi: 10.7759/cureus.31973. eCollection 2022 Nov.

Treatment, Survival, and Demographics in Temporal Bone Malignancies: A Pooled Data Analysis

Mitchell R Gore  1
Affiliations
Review

Treatment, Survival, and Demographics in Temporal Bone Malignancies: A Pooled Data Analysis

Mitchell R Gore. Cureus. .

Abstract

Temporal bone malignancies are relatively uncommon tumors. Their location adjacent to vital structures such as the carotid artery, jugular vein, otic capsule, and temporal lobe can make their treatment potentially challenging. The purpose of this study was to compare outcomes in temporal bone malignancies obtained via pooled literature data. The study sought to examine factors affecting survival in temporal bone malignancies based on the studies in the existing published literature. A systematic search was conducted on the PubMed (Medline), Embase, and Google Scholar databases to identify relevant studies from 1951 to 2022 that described the treatment of temporal bone malignancies. Articles that fulfilled the inclusion criteria were assessed and analyzed by the author. The literature search identified 5875 case series and case reports, and 161 of them contained sufficient data to be included in the pooled data analysis, involving a total of 825 patients. Multivariate analysis of the pooled literature data showed that overall stage, presence of facial palsy, and surgical margin status significantly affected overall survival (OS), while overall stage and presence of facial palsy significantly affected disease-free survival (DFS). To summarize, this study examined pooled survival data on demographics, treatment, and survival of patients with temporal bone malignancies utilizing an extensive literature-based pooled data meta-analysis. Overall stage, facial nerve status, and surgical margin status appeared to most strongly affect survival in patients with temporal bone malignancies.

Keywords: cancer; ear; head and neck; oncology; survival.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA study selection flow diagram for the systematic literature search
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Figure 2
Figure 2. Kaplan-Meier overall survival for the entire literature-based temporal bone malignancy cohort
Figure 3
Figure 3. Kaplan-Meier disease-free survival for the entire literature-based temporal bone malignancy cohort
Figure 4
Figure 4. Kaplan-Meier overall survival by overall stage for literature-based temporal bone malignancy cohort
Figure 5
Figure 5. Kaplan-Meier disease-free survival by overall stage for literature-based temporal bone malignancy cohort
Figure 6
Figure 6. Kaplan-Meier overall survival by T (tumor) stage for literature-based temporal bone malignancy cohort
Figure 7
Figure 7. Kaplan-Meier disease-free survival by T (tumor) stage for literature-based temporal bone malignancy cohort
Figure 8
Figure 8. Kaplan-Meier overall survival by N (nodal) stage for literature-based temporal bone malignancy cohort
Figure 9
Figure 9. Kaplan-Meier disease-free survival by N (nodal) stage for literature-based temporal bone malignancy cohort
Figure 10
Figure 10. Kaplan-Meier overall survival by M (metastasis) stage for literature-based temporal bone malignancy cohort
Figure 11
Figure 11. Kaplan-Meier disease-free survival by M (metastasis) stage for literature-based temporal bone malignancy cohort
Figure 12
Figure 12. Kaplan-Meier overall survival by tumor grade for literature-based temporal bone malignancy cohort
Figure 13
Figure 13. Kaplan-Meier disease-free survival by tumor grade for literature-based temporal bone malignancy cohort
Figure 14
Figure 14. Kaplan-Meier overall survival by histopathological type for literature-based temporal bone malignancy cohort
Figure 15
Figure 15. Kaplan-Meier disease-free survival by histopathological type for literature-based temporal bone malignancy cohort
Figure 16
Figure 16. Kaplan-Meier overall survival by the presence or absence of facial palsy for literature-based temporal bone malignancy cohort
Figure 17
Figure 17. Kaplan-Meier disease-free survival by the presence or absence of facial palsy for literature-based temporal bone malignancy cohort
Figure 18
Figure 18. Kaplan-Meier overall survival by the presence or absence of hearing loss for literature-based temporal bone malignancy cohort
Figure 19
Figure 19. Kaplan-Meier disease-free survival by the presence or absence of hearing loss for literature-based temporal bone malignancy cohort
Figure 20
Figure 20. Kaplan-Meier overall survival by margin status for literature-based temporal bone malignancy cohort
NA: not applicable
Figure 21
Figure 21. Kaplan-Meier disease-free survival by margin status for literature-based temporal bone malignancy cohort
NA: not applicable
Figure 22
Figure 22. Kaplan-Meier overall survival by treatment type for literature-based temporal bone malignancy cohort
S: surgery; R: radiation; C: chemotherapy
Figure 23
Figure 23. Kaplan-Meier disease-free survival by treatment type for literature-based temporal bone malignancy cohort
S: surgery; R: radiation; C: chemotherapy
Figure 24
Figure 24. Kaplan-Meier overall survival by type of surgery for literature-based temporal bone malignancy cohort
Figure 25
Figure 25. Kaplan-Meier disease-free survival by type of surgery for literature-based temporal bone malignancy cohort
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