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. 2023 Jun;18(6):1269-1270.
doi: 10.4103/1673-5374.360170.

Putting PLX5622 into perspective: microglia in central nervous system viral infection

Alanna G Spiteri  1 , Nicholas J C King  2
Affiliations

Putting PLX5622 into perspective: microglia in central nervous system viral infection

Alanna G Spiteri et al. Neural Regen Res. 2023 Jun.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
PLX5622 inhibits bone marrow monocyte production, reducing neuroinflammation and CNS infiltration following WNV infection. Treating mice with PLX5622 21 days prior to WNV-infection and until 7 days post-injury significantly reduces 1) monocyte proliferation in the bone marrow and 2) the number of microglia potentially producing pro-inflammatory cytokines and chemotactic molecules. This results in a substantial reduction in the recruitment of immune cells into the CNS, including nitric oxide-producing monocyte-derived cells (MCs) and neutrophils, and interferon gamma (IFN-γ)-producing T cells, remarkably reducing neuroinflammation and the disease phenotype, highlighting a protective role for PLX5622 in infection and monocyte-mediated disease. CNS: Central nervous system; IFN-γ: interferon gamma; IL-1α: interleukin-1 alpha; MC: monocyte-derived cells; TNF: tumour necrosis factor; WNV: West Nile virus.
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