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Meta-Analysis
. 2023 Jun;19(6):2265-2275.
doi: 10.1002/alz.12828. Epub 2022 Dec 1.

Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Yvonne Leung  1 , Nir Barzilai  2 , Agnieszka Batko-Szwaczka  3 , Nina Beker  4 , Kathrin Boerner  5 , Carol Brayne  6 , Henry Brodaty  1 , Karen Siu-Lan Cheung  7 , María M Corrada  8 , John D Crawford  1 , Alessia A Galbussera  9 , Yasuyuki Gondo  10 , Henne Holstege  11 , Marc Hulsman  11 , Yoshiko Lily Ishioka  12 , Daniela Jopp  13 , Claudia H Kawas  8 , Jeff Kaye  14 , Nicole A Kochan  1 , Bobo Hi-Po Lau  15 , Darren M Lipnicki  1 , Jessica W Lo  1 , Ugo Lucca  9 , Steve R Makkar  1 , Gabriella Marcon  16   17 , Peter Martin  18 , Kenichi Meguro  19 , Sofiya Milman  2 , Leonard W Poon  20 , Angela Recchia  9 , Oscar Ribeiro  21 , Emma Riva  9 , Christoph Rott  22 , Sietske Am Sikkes  4   23 , Ingmar Skoog  24 , Blossom Stephan  25 , Jan Szewieczek  3 , Laetitia Teixeira  21 , Mauro Tettamanti  26 , Krzysztof Wilczyński  3 , Perminder Sachdev  1
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Free article
Meta-Analysis

Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies

Yvonne Leung et al. Alzheimers Dement. 2023 Jun.
Free article

Abstract

Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100.

Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed.

Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92-0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35-0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI).

Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.

Keywords: centenarians; dementia; education; exceptional longevity; prevalence; risk factors.

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References

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