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. 2022 Dec 16;24(49):9076-9080.
doi: 10.1021/acs.orglett.2c03714. Epub 2022 Dec 1.

Stereoselective Preparation of CF3-Containing Cyclopropanes

Veronika Myronova  1   2 , Dominique Cahard  2 , Ilan Marek  1
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Stereoselective Preparation of CF3-Containing Cyclopropanes

Veronika Myronova et al. Org Lett. .

Abstract

A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.

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