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. 2023 Mar;89(3):939-941.
doi: 10.1111/bcp.15605. Epub 2022 Dec 1.

Hyperbaric oxygen should be used for carbon monoxide poisoning

Kinjal Sethuraman  1 , Stephen R Thom  1
Affiliations

Hyperbaric oxygen should be used for carbon monoxide poisoning

Kinjal Sethuraman et al. Br J Clin Pharmacol. 2023 Mar.

Abstract

This short review addresses the mechanisms of injury mediated by carbon monoxide (CO) and current information on efficacy of hyperbaric oxygen therapy (HBOT). Recent clinical series involving large, country-wide databases and prospective randomized trials are summarized. We conclude that there is an abundance of basic science and preclinical and clinical research supporting the use of HBOT for acute CO poisoning. With appropriate consideration for pathology and therapeutic mechanisms, HBOT at a dose of 2.5-3.0 atm absolute is a necessary treatment for this toxidrome.

Keywords: carboxyhaemoglobin; neurological sequelae; randomized trials; β2 integrins.

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Conflict of interest statement

Competing interests: The authors have no conflicts of interest to declare.

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