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. 2022 Oct;39(5):972-975.
doi: 10.5114/ada.2021.113127. Epub 2022 Feb 4.

Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study

Anna Malewska-Woźniak  1 , Martha Lodyga  1 , Zygmunt Adamski  1
Affiliations

Concentrations of metalloproteinase-1 in patients with morphea treated with phototherapy: a preliminary study

Anna Malewska-Woźniak et al. Postepy Dermatol Alergol. 2022 Oct.

Abstract

Introduction: Morphea (localized scleroderma) is a rare, chronic, inflammatory connective tissue disease, characterized by immune system dysfunction, vasculopathy and skin fibrosis. One of the most effective treatments is phototherapy. Phototherapy has been found to be effective in treating localized scleroderma by inducing the expression of metalloproteinase-1.

Aim: To compare the concentrations of metalloproteinase (MMP-1) before psoralen and ultraviolet A (PUVA) and ultraviolet A1 (UVA1) treatments in the serum of patients with morphea.

Material and methods: The observational study was conducted in one research centre and included patients with generalised morphea who were treated with PUVA and UVA1 phototherapies. The mean age of all morphea patients included in the study was 55.7 years. The levels of MMP-1 were examined by ELISA (The Biorbyt Human MMP-1 ELISA - Enzyme-Linked Immunosorbent Assay).

Results: The study showed that patients treated with PUVA and UVA1 had an improvement based on clinical measures, resulting in a reduction of clinical score. However, we did not observe statistically significant differences in MMP-1 concentrations before and after treatment. Limitations: The study sample was relatively small. Further studies on a larger group of patients would be beneficial.

Conclusions: Our data suggest that there is a possible correlation between MMP-1 concentrations and phototherapy. MMP-1 levels were found to be increased following phototherapy treatment, which may suggest a correlation with better response to treatment in patients with morphea. However, further research is needed.

Keywords: PUVA; UVA1; localized scleroderma; matrix metalloproteinase-1; morphea; phototherapy; psoralen and ultraviolet A; ultraviolet A1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Clinical stages of morphea – inflammation
Figure 2
Figure 2
Clinical stages of morphea – sclerosis
Figure 3
Figure 3
Clinical stages of morphea – atrophy with hyperpigmentation and scar after biopsy taken
Figure 4
Figure 4
LoSCAT values before and after phototherapy in patients with morphea (p = 0.0001)
Figure 5
Figure 5
Concentrations of MMP-1 before and after phototherapy (p = 0.1441)
See this image and copyright information in PMC

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