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. 2022 Nov 2:13:513-522.
doi: 10.1016/j.ibneur.2022.10.016. eCollection 2022 Dec.

Subjective cognitive impairment is related to work status in people with multiple sclerosis

J van Wegen  1 , E E A van Egmond  2   3   4   5 , R H B Benedict  6 , E A C Beenakker  7 , J J J van Eijk  8 , S T F M Frequin  9 , K de Gans  10 , O H H Gerlach  11 , D A M van Gorp  3 , G J D Hengstman  12 , P J Jongen  13   14 , J J L van der Klink  15   16 , M F Reneman  14 , W I M Verhagen  17 , H A M Middelkoop  2   18 , L H Visser  3   5 , H E Hulst  2 , K van der Hiele  2
Affiliations

Subjective cognitive impairment is related to work status in people with multiple sclerosis

J van Wegen et al. IBRO Neurosci Rep. .

Abstract

Background: Unemployment is common among people with multiple sclerosis (pwMS) and has been associated with subjective cognitive difficulties, specifically in memory, attention, and executive functioning. However, longitudinal research on subjective cognitive difficulties and employment is scarce.

Objective: We investigated whether subjective cognitive impairment (SCI), based on the clinical cut-off score of the MS Neuropsychological Screening Questionnaire (MSNQ), was associated with work status and negative work events (NWE) at baseline and after 2 years. Moreover, we investigated whether four MSNQ subdomains were related to work status and NWE.

Methods: 287 participants (77.4% female, median age = 42 years) completed questionnaires on subjective cognitive functioning, depression, anxiety, and fatigue, and completed the Symbol Digit Modalities Test (SDMT). After baseline comparisons, logistic regression analyses were performed, with work status and NWE at baseline, and employment change and NWE change within 2 years after baseline as dependent variables. Independent variables included SCI and the MSNQ domains. Covariates anxiety, depression, fatigue, and SDMT were added.

Results: SCI, depression and anxiety were associated with work status (Nagelkerke R 2 = .286), but only SCI was associated with employment change (Nagelkerke R 2 = .164). No predictors were associated with NWE at baseline or follow-up. In addition, no MSNQ subdomain was related to work status, employment change or NWE.

Conclusion: Unemployed pwMS and pwMS with a deteriorated work status reported more cognitive difficulties after 2 years than employed pwMS or pwMS with a stable work status. In addition, depression, and anxiety were associated with work status.

Keywords: Cognitive impairment; Multiple sclerosis; Subjective cognitive difficulties; Work participation; Work status.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Abma F.I., Van der Klink J.J.L., Bültmann U. The work role functioning questionnaire 2.0 (Dutch Version): examination of its reliability, validity and responsiveness in the general working population. J. Occup. Rehabil. 2013;23(1):135–147. doi: 10.1007/s10926-012-9379-8. - DOI - PubMed
    1. Baughman B.C., Basso M.R., Sinclair R.R., Combs D.R., Roper B.L. Staying on the job: the relationship between work performance and cognition in individuals diagnosed with multiple sclerosis. J. Clin. Exp. Neuropsychol. 2015;37(6):630–640. doi: 10.1080/13803395.2015.1039963. - DOI - PMC - PubMed
    1. Benedict R.H.B., Rodgers J.D., Emmert N., Kiniger R., Weinstock-Guttman B. Negative work events and accommodations in employed multiple sclerosis patients. Mult. Scler. J. 2014;20(1):116–119. doi: 10.1177/1352458513494492. - DOI - PubMed
    1. Benedict R.H.B., Zivadinov R. Predicting neuropsychological abnormalities in multiple sclerosis. J. Neurol. Sci. 2006;245(1–2):67–72. doi: 10.1016/j.jns.2005.05.020. - DOI - PubMed
    1. Benedict R.H.B., Munschauer F., Linn R., Miller C., Murphy E., Foley F., Jacobs L. Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Mult. Scler. 2003;9(1):95–101. doi: 10.1191/1352458503ms861oa. - DOI - PubMed

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