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Editorial
. 2022 Nov 7;18(6):1429-1434.
doi: 10.5114/aoms/156147. eCollection 2022.

2022: the year in cardiovascular disease - the year of upfront lipid lowering combination therapy

Maciej Banach  1   2   3 , Zeljko Reiner  4 , Arrigo F G Cicero  5   6 , Pierre Sabouret  7 , Margus Viigimaa  8   9 , Amirhossein Sahebkar  10   11   12   13 , Arman Postadzhiyan  14 , Dan Gaita  15   16 , Daniel Pella  17 , Peter E Penson  18   19
Affiliations
Editorial

2022: the year in cardiovascular disease - the year of upfront lipid lowering combination therapy

Maciej Banach et al. Arch Med Sci. .
No abstract available

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Conflict of interest statement

Maciej Banach: speakers bureau: Amgen, Daichii Sankyo, KRKA, Polpharma, Mylan/Viatris, Novartis, Novo-Nordisk, Sanofi-Aventis, Teva, Zentiva; consultant to Amgen, Daichii Sankyo, Esperion, NewAmsterdam, Novartis, Novo-Nordisk, Polfarmex, Sanofi-Aventis; Grants from Amgen, Daichii Sankyo, Mylan/Viatris, Sanofi and Valeant; Zeljko Reiner: speakers bureau: Sanofi, Novartis; Margus Viigimaa: speakers bureau: Amgen, Novartis, Novo-Nordisk, Sanofi-Aventis, Menarini; Arman Postadzhiyan: speakers bureau: Amgen, Novartis, Novo-Nordisk, Teva, Zentiva; Daniel Pella: received honoraria for events sponsored by Amgen, Jamieson, Novartis, MSD, Pfizer, Servier; Peter E. Penson owns four shares in AstraZeneca PLC and has received honoraria and/or travel reimbursement for events sponsored by AKCEA, Amgen, AMRYT, Link Medical, Mylan, Napp, Sanofi; all other authors have no conflict of interest.

Figures

Figure 1
Figure 1
How to be effective with lipid lowering therapy in ASCVD patients (the size of the LDL-C reduction for some recommended combinations is an assumption and still needs to be confirmed) *FDC of high intensity statin therapy and ezetimibe is a preferable option for all ASCVD patients. ASCVD – atherosclerotic cardiovascular disease, LDL-C – low-density lipoprotein cholesterol, ASC – acute coronary syndrome, PAD – peripheral artery disease, HIS – high intensity statin therapy, FDC – fixed dose combination, EZE – ezetimibe, BA – bempedoic acid, PCSK9i – proprotein convertase subtilisin/kexin 9 targeted approach therapy (PCSK9 inhibitors + inclisiran).
See this image and copyright information in PMC

References

    1. Sabouret P, Angoulvant D, Cannon CP, Banach M. Low levels of low-density lipoprotein cholesterol, intracerebral haemorrhage, and other safety issues: is there still a matter of debate? Eur Heart J Open 2022; 2: oeac038. - PMC - PubMed
    1. Ray KK, Molemans B, Schoonen WM, et al.; DA VINCI study . EU-Wide cross-sectional observational study of lipid-modifying therapy use in secondary and primary care: the DA VINCI study. Eur J Prev Cardiol 2021; 28: 1279-89. - PubMed
    1. Vrablik M, Seifert B, Parkhomenko A, et al. Lipid-lowering therapy use in primary and secondary care in Central and Eastern Europe: DA VINCI observational study. Atherosclerosis 2021; 334: 66-75. - PubMed
    1. Lyall DM, Ward J, Banach M, et al. PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study. Arch Med Sci 2021; 17: 241-4. - PMC - PubMed
    1. Banach M, López-Sendon JL, Averna M, et al. Treatment adherence and effect of concurrent statin intensity on the efficacy and safety of alirocumab in a real-life setting: results from ODYSSEY APPRISE. Arch Med Sci 2022; 18: 285-92. - PMC - PubMed

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