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. 2022 Nov 25:27:488-490.
doi: 10.1016/j.omtm.2022.11.002. eCollection 2022 Dec 8.

A retrograde approach for liver gene transfer

Nicola Brunetti-Pierri  1   2   3 , Paul Gissen  4   5   6
Affiliations

A retrograde approach for liver gene transfer

Nicola Brunetti-Pierri et al. Mol Ther Methods Clin Dev. .
No abstract available

Keywords: gene therapy; hydrodynamic injections; hydrodynamic retrograde intrabiliary injection; nonviral vectors; ornithine transcarbamylase deficiency.

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Conflict of interest statement

P.G. is a co-founder of Bloomsbury Genetic Therapies.

Figures

Figure 1
Figure 1
Hepatocytes are arranged in liver lobules that receive oxygenated blood from the heart via the hepatic artery (red) and deoxygenated blood via the portal vein (blue). Bile drains from hepatocytes via the hepatic ducts (green). Hydrodynamic retrograde intrabiliary injection (HRII) is performed by surgical procedure entailing laparotomy and vector delivery via a catheter placed within the common bile duct, which results in retrograde flow through bile ducts and transfection of mostly periportal hepatocytes where OTC is expressed. This figure was created with BioRender.com.
See this image and copyright information in PMC

References

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