Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec;62(4):516-523.
doi: 10.1007/s12088-022-01040-x. Epub 2022 Sep 12.

Prospecting Microbial Genomes for Biomolecules and Their Applications

Vipin Chandra Kalia #  1 , Chunjie Gong #  2 , Ramasamy Shanmugam  1 , Jung-Kul Lee  1
Affiliations
Review

Prospecting Microbial Genomes for Biomolecules and Their Applications

Vipin Chandra Kalia et al. Indian J Microbiol. 2022 Dec.

Abstract

Bioactive molecules of microbial origin are finding increasing biotechnological applications. Their sources range from the terrestrial, marine, and endophytic to the human microbiome. These biomolecules have unique chemical structures and related groups, which enable them to improve the efficiency of the bioprocesses. This review focuses on the applications of biomolecules in bioremediation, agriculture, food, pharmaceutical industries, and human health.

Keywords: Antibacterials; Anticancer; Bioactive products; Metagenomics; Therapeutics.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestAll authors declare that there is no actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within five years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work.

Figures

None
Figure 1 Biomolecules of diverse origins obtained through metagenomic approaches from terrestrial and marine sources
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Scherlach K, Hertweck C. Mining and unearthing hidden biosynthetic potential. Nat Commun. 2021;12:3864. doi: 10.1038/s41467-021-24133-5. - DOI - PMC - PubMed
    1. Matuszewska A, Jaszek M, Stefaniuk D, et al. Anticancer, antioxidant, and antibacterial activities of low molecular weight bioactive subfractions isolated from cultures of wood degrading fungus Cerrena unicolor. PLoS ONE. 2018;13:e0197044. doi: 10.1371/journal.pone.0197044. - DOI - PMC - PubMed
    1. Adeleke BS, Babalola OO. Biotechnological overview of agriculturally important endophytic fungi. Hortic Environ Biotechnol. 2021;62:507–520. doi: 10.1007/s13580-021-00334-1. - DOI
    1. Abdel-Mageed W, Milne B, Wagner M, et al. Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment. Org Biomol Chem. 2010;8:2352–2362. doi: 10.1039/c001445a. - DOI - PubMed
    1. Graça A, Bondoso J, Gaspar H, et al. Antimicrobial activity of heterotrophic bacterial communities from the marine sponge Erylus discophorus (astrophorida, geodiidae) PLoS ONE. 2013;8:e78992. doi: 10.1371/journal.pone.0078992. - DOI - PMC - PubMed

LinkOut - more resources