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. 2022 Nov 21;8(11):e11786.
doi: 10.1016/j.heliyon.2022.e11786. eCollection 2022 Nov.

Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants

Yan-Yan Li  1   2 , Hui Wang  3 , Yang-Yang Zhang  4
Affiliations

Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants

Yan-Yan Li et al. Heliyon. .

Abstract

Background and aims: It has been indicated that Melatonin receptor 1B (MTNR1B) gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reached now. Hence, the present meta-analysis was conducted to illuminate the potential association of human MTNR1B gene rs10830963 C/G polymorphism and T2DM.

Methods and results: There were 13,752 participants from 7 studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed by using the fixed or random effects models. A significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM was found under recessive (OR: 1.148, 95% CI: 1.052-1.253, P = 0.002), homozygous (OR: 1.197, 95% CI: 1.023-1.401, P = 0.025), and additive (OR: 1.067, 95% CI: 1.017-1.120, P = 0.008) genetic models.

Conclusions: MTNR1B gene rs10830963 C/G polymorphism was significantly related to T2DM in the Chinese population. The persons with G allele of the MTNRB1 gene rs10830963 C/G polymorphism might be the T2DM susceptible population.

Keywords: Genetic; MTNR1B; Polymorphism; Type 2 diabetes mellitus; rs10830963.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under an allelic genetic model (i.e. G allele vs. G allele + C allele of MTNR1B gene rs10830963 C/G polymorphism).
Figure 2
Figure 2
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under a recessive genetic model (i.e. GG VS. CC + CG of MTNR1B gene rs10830963 C/G polymorphism).
Figure 3
Figure 3
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under a dominant genetic model (i.e. CC VS. GG + CG of MTNR1B gene rs10830963 C/G polymorphism).
Figure 4
Figure 4
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under a heterozygous genetic model (i.e., CG vs. CC of MTNR1B gene rs10830963 C/G polymorphism).
Figure 5
Figure 5
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under a homozygous genetic model (i.e., GG vs. CC of MTNR1B gene rs10830963 C/G polymorphism).
Figure 6
Figure 6
Forest plot of T2DM associated with MTNR1B gene rs10830963 C/G polymorphism under an additive genetic model (i.e., G allele vs. C allele of MTNR1B gene rs10830963 C/G polymorphism).
Figure 7
Figure 7
The funnel plot for studies of the association of T2DM and MTNR1B gene rs10830963 C/G polymorphism under a recessive genetic model (i.e. GG VS.CC + CG of MTNR1B gene rs10830963 C/G polymorphism). The horizontal and vertical axes correspond to the OR on log scale and SE (logOR), respectively. OR: odds ratio; SE: standard error.
Figure 8
Figure 8
The Begg's funnel plot for studies of the association of T2DM and MTNR1B gene rs10830963 C/G polymorphism under an additive genetic model (i.e., G allele vs. C allele of MTNR1B gene rs10830963 C/G polymorphism). The horizontal and vertical axes correspond to the OR on log scale and SE (logOR), respectively. OR: odds ratio; SE: standard error.
Figure 9
Figure 9
The sensitivity analysis on the association of T2DM and MTNR1B gene rs10830963 C/G polymorphism under an additive genetic model (i.e., G allele vs. C allele of MTNR1B gene rs10830963 C/G polymorphism).
See this image and copyright information in PMC

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