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Review
. 2022 Jan-Dec:10:23247096221141190.
doi: 10.1177/23247096221141190.

Undifferentiated Pleomorphic Sarcoma Presenting With Cardiac Tamponade: A Case Report and Review

Swathi Prakash  1 , Jose Luis Rayas  1 , Adrian Rojas Murguia  1 , Ajay Lingireddy  1 , Mariam Hassan  1 , Sara Alhariri  1 , M Nawar Hakim  1 , Fatma Dihowm  1 , Satish Maharaj  1
Affiliations
Review

Undifferentiated Pleomorphic Sarcoma Presenting With Cardiac Tamponade: A Case Report and Review

Swathi Prakash et al. J Investig Med High Impact Case Rep. 2022 Jan-Dec.

Abstract

Soft tissue sarcomas (STS) comprise a large group of heterogeneous malignant tumors that form approximately 1% of all adult malignancies. Most sarcomas originate from soft tissue and the rest arise from the bone. Undifferentiated pleomorphic sarcoma (UPS) is an aggressive tumor that usually presents as an asymptomatic subcutaneous mass that exhibits rapid growth with unremarkable skin findings. The diagnosis is usually made with histopathology or immunohistochemistry; once the diagnosis is confirmed, evaluation and workup of the primary tumor, lymph nodes, and metastasis should be made. Treatment is stage-dependent but generally involves en-bloc resection followed by a review of pathology with a discussion of the benefits of adjuvant radiation or chemotherapy. Here, we discuss a case of a 77-year-old patient who presented with a large mass over the right shoulder and echocardiographic findings of cardiac tamponade.

Keywords: cardiology; hematology oncology.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Computed tomography scan of right upper extremity revealing an 11.2 cm × 14.2 cm × 8.8 cm right shoulder mass with osseous erosion of the inferior right scapula.
Figure 2.
Figure 2.
The low-power view shows a very cellular tumor (Hematoxylin & Eosin stain, original magnification ×200).
Figure 3.
Figure 3.
The high-power view shows malignant tumor cells with large and pleomorphic nuclei, a moderate amount of cytoplasm, prominent nucleoli, and some mitotic figures (arrow). Hematoxylin & Eosin stain, original magnification ×400.
Figure 4.
Figure 4.
The tumor contains several osteoblastic-like multinucleated giant cells (arrows). Hematoxylin & Eosin stain, original magnification ×400.
See this image and copyright information in PMC

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