Conflict of interest: C.M. has received research support from the Swiss National Science Foundation, the Swiss Heart Foundation, the KTI, the University Hospital Basel, the University of Basel, Beckman Coulter, Biomerieux, Brahms, Mitsubishi, Novartis, Ortho Clinical, Quidel, Roche, Siemens, Singulex, and Sphingotec, as well as speaker honoraria/consulting honoraria from Astra Zeneca, Bayer, Boehringer Ingelheim, BMS, Osler, Novartis, Roche, Siemens, SpinChip, and Singulex, outside the submitted work, and all paid to the institution. R.A.dB has received research grants and/or fees from AstraZeneca, Abbott, Boehringer Ingelheim, Cardior Pharmaceuticals GmbH, Ionis Pharmaceuticals, Inc., Novo Nordisk, and Roche; and has had speaker engagements with Abbott, AstraZeneca, Bayer, Bristol Myers Squibb, Novartis, and Roche. T.S.M.-G. declares no conflict of interest with this study.