Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul;315(5):1109-1128.
doi: 10.1007/s00403-022-02487-0. Epub 2022 Dec 2.

Psoriasis in the transplant population

Nathanael C Jensen  1 , Jacob Robins  2 , Ashley M Snyder  2   3 , Ryan Harris  4 , Laura Korb Ferris  5 , Luke Johnson  6
Affiliations
Review

Psoriasis in the transplant population

Nathanael C Jensen et al. Arch Dermatol Res. 2023 Jul.

Abstract

Solid organ and stem cell transplants are increasingly common, and dermatologists will more frequently encounter and need to manage common skin diseases, such as psoriasis, in transplant patients. This review explores psoriasis remission and occurrence in recipients of solid organ and stem cell transplants. Hematopoietic and mesenchymal stem cell transplants may show potential for treating psoriasis in patients with leukemia or who have other medical conditions requiring stem cell transplant. The effects of solid organ transplant are less clear, partly due to limitations in the breadth of the literature. De novo psoriasis has been reported in recipients of solid organ transplants, but the reasons for this development have yet to be fully understood. Overall, the literature on this subject is limited to primarily case reports. Feasibility of studies on the subject may be a considerable barrier to further research assessing the use of transplant for treating psoriasis, but there is potential benefit from transplant for psoriasis patients. This subject should receive further exploration to fully understand these benefits.

Keywords: Organ; Psoriasis; Review; Stem cell; Therapy; Transplant.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest Ryan Harris has served as an investigator for Bristol Meyers Squib and Eli Lilly. Laura Korb Ferris has received compensation for participation as an investigator in clinical trials from Amgen, Abbvie, UCB, Eli Lilly, Novartis, Janssen, Nimbus, Dermavant, and Arcutis. Dr. Ferris has received consulting honoraria from Eli Lilly, Abbvie, Arcutis, Dermavant, Janssen, Bristol-Myers Squibb, Ortho Bausch, and Sun Pharma. Dr. Ferris has received honoraria for participating in data safety monitoring boards from Bristol-Myers Squibb and Pfizer. Luke Johnson co-hosts the not-for-profit podcasts Dermasphere and Skincast. All other authors have no conflicts to declare.

References

    1. Organ Procurement and Transplantation Network, U.S. Department of Health & Human Services. National data [Internet]. Organ Procurement and Transplantation Network, U.S. Department of Health & Human Services. https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/. Accessed 30 Mar 2022
    1. Niederwieser D, Baldomero H, Atsuta Y et al. (2019) One and half million hematopoietic stem cell transplants (HSCT). Dissemination, trends and potential to improve activity by telemedicine from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Blood 134(Supplement 1):2035. 10.1182/blood-2019-125232 - DOI
    1. Rachakonda TD, Schupp CW, Armstrong AW (2014) Psoriasis prevalence among adults in the United States. J Am Acad Dermatol 70(3):512–516. 10.1016/j.jaad.2013.11.013 - DOI - PubMed
    1. Helmick CG, Lee-Han H, Hirsch SC et al. (2014) Prevalence of psoriasis among adults in the U.S.: 2003–2006 and 2009–2010 national health and nutrition examination surveys. Am J Prev Med 47(1):37–45. 10.1016/j.amepre.2014.02.012 - DOI - PMC - PubMed
    1. Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323(19):1945–1960. 10.1001/jama.2020.4006 - DOI - PubMed