Fishing with autoantibodies nets a gut bacteria that drives arthritis

Affiliations

Comment

Rachael A Clark. Sci Immunol. 2022.

. 2022 Dec 9;7(78):eadf9316.

doi: 10.1126/sciimmunol.adf9316. Epub 2022 Dec 2.

¹ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; email: rclark@bwh.harvard.edu.

Abstract

A fecal bacterial strain cross-reacts with rheumatoid arthritis autoantibodies, stimulates CD4⁺ T cells, and induces joint disease in mice.

Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum.
Chriswell ME, Lefferts AR, Clay MR, Hsu AR, Seifert J, Feser ML, Rims C, Bloom MS, Bemis EA, Liu S, Maerz MD, Frank DN, Demoruelle MK, Deane KD, James EA, Buckner JH, Robinson WH, Holers VM, Kuhn KA. Chriswell ME, et al. Sci Transl Med. 2022 Oct 26;14(668):eabn5166. doi: 10.1126/scitranslmed.abn5166. Epub 2022 Oct 26. Sci Transl Med. 2022. PMID: 36288282 Free PMC article.