Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Jorine E Hartman¹, Felix J F Herth², Pallav Shah³, Christophe Pison⁴, Arschang Valipour⁵, Dirk-Jan Slebos⁶; AIRFLOW-2 Study Group

Collaborators, Affiliations

Collaborators

AIRFLOW-2 Study Group:
Arschang Valipour, Christine Abele, Irene Firlinger, Kiran Kothakuzhakal, Marina Duller, Bernd Lamprecht, Roland Kropfmueller, Kornelia Holzmann, Sandra Rathmeier, Ralf Hubner, Leonore Erdmann, Bettina Temmesfeld-Wollbrück, Christoph Ruwwe Glösenkamp, Wolfgang Gesierich, Frank Reichenberger, Christa Niehaus, Felix Herth, Ralf Eberhardt, Daniela Gompelmann, Brigitte Rump, Kaid Darwiche, Stephan Eisenmann, Ulrike Kaiser, Birte Schwarz, Ulrike Sampel, Christian Schumann, Robert Kaiser, Kathryn Schumann-Stoiber, Dirk Skowasch, Sabine Ring, Christophe Pison, Amandine Briault, Francois Arbib, Marie Jondot, Thierry Perez, Clement Fournier, Regis Matran, Michele Catto, Nathalie Bautin, Virginie De Broucker, Marie Willemin, Anne Prevotat, Ludivine Wemeau, Alice Gicquello, Morgane Foulon, Hasna Camara, Gaetan Deslee, Herve Vallerand, Sandra Dury, Delphine Gras, Margaux Bonnaire-Verdier, Romain Kessler, Sandrine Hirschi, Michele Porzio, Tristan Degot, Mathieu Canuet, Armelle Schuller, Julien Stauder, Sahra Ali Azouaou, Armelle Marceau, Hervé Mal, Yolande Costa, Pallav L Shah, Justin Garner, Karthi Srikanthan, Cielito Caneja, John Thornton, Dirk-Jan Slebos, Nick Ten Hacken, Jorine Hartman, Karin Klooster, Sonja Augustijn, Peter Bonta, Jouke Annema, Marianne van de Pol, Annika Goorsenberg

Affiliations

¹ Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. Electronic address: j.hartman@umcg.nl.
² Department of Pneumology and Critical Care Medicine, Thoraxklinik and Translational Lung Research Center, University of Heidelberg, Germany.
³ Royal Brompton Hospital, London, United Kingdom; Chelsea & Westminster Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
⁴ Service Hospitalier Universitaire de Pneumologie Physiologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France; Centre de Pneumologie Henri Bazire, Saint Julien de Ratz, France; Département Universitaire des Patients Grenoble Alpes, Faculté de Médecine Pharmacie, Université Grenoble Alpes, La Tronche, France.
⁵ Department of Respiratory and Critical Care Medicine, Vienna Health Care Group, Klinik Floridsdorf, Vienna, Austria.
⁶ Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

PMID: 36459953
DOI: 10.1016/j.rmed.2022.107059

Free article

Clinical Trial

Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Jorine E Hartman et al. Respir Med. 2023 Jan.

Free article

. 2023 Jan:206:107059.

doi: 10.1016/j.rmed.2022.107059. Epub 2022 Nov 26.

Authors

Jorine E Hartman¹, Felix J F Herth², Pallav Shah³, Christophe Pison⁴, Arschang Valipour⁵, Dirk-Jan Slebos⁶; AIRFLOW-2 Study Group

Collaborators

AIRFLOW-2 Study Group:
Arschang Valipour, Christine Abele, Irene Firlinger, Kiran Kothakuzhakal, Marina Duller, Bernd Lamprecht, Roland Kropfmueller, Kornelia Holzmann, Sandra Rathmeier, Ralf Hubner, Leonore Erdmann, Bettina Temmesfeld-Wollbrück, Christoph Ruwwe Glösenkamp, Wolfgang Gesierich, Frank Reichenberger, Christa Niehaus, Felix Herth, Ralf Eberhardt, Daniela Gompelmann, Brigitte Rump, Kaid Darwiche, Stephan Eisenmann, Ulrike Kaiser, Birte Schwarz, Ulrike Sampel, Christian Schumann, Robert Kaiser, Kathryn Schumann-Stoiber, Dirk Skowasch, Sabine Ring, Christophe Pison, Amandine Briault, Francois Arbib, Marie Jondot, Thierry Perez, Clement Fournier, Regis Matran, Michele Catto, Nathalie Bautin, Virginie De Broucker, Marie Willemin, Anne Prevotat, Ludivine Wemeau, Alice Gicquello, Morgane Foulon, Hasna Camara, Gaetan Deslee, Herve Vallerand, Sandra Dury, Delphine Gras, Margaux Bonnaire-Verdier, Romain Kessler, Sandrine Hirschi, Michele Porzio, Tristan Degot, Mathieu Canuet, Armelle Schuller, Julien Stauder, Sahra Ali Azouaou, Armelle Marceau, Hervé Mal, Yolande Costa, Pallav L Shah, Justin Garner, Karthi Srikanthan, Cielito Caneja, John Thornton, Dirk-Jan Slebos, Nick Ten Hacken, Jorine Hartman, Karin Klooster, Sonja Augustijn, Peter Bonta, Jouke Annema, Marianne van de Pol, Annika Goorsenberg

Affiliations

¹ Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands. Electronic address: j.hartman@umcg.nl.
² Department of Pneumology and Critical Care Medicine, Thoraxklinik and Translational Lung Research Center, University of Heidelberg, Germany.
³ Royal Brompton Hospital, London, United Kingdom; Chelsea & Westminster Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
⁴ Service Hospitalier Universitaire de Pneumologie Physiologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France; Centre de Pneumologie Henri Bazire, Saint Julien de Ratz, France; Département Universitaire des Patients Grenoble Alpes, Faculté de Médecine Pharmacie, Université Grenoble Alpes, La Tronche, France.
⁵ Department of Respiratory and Critical Care Medicine, Vienna Health Care Group, Klinik Floridsdorf, Vienna, Austria.
⁶ Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

PMID: 36459953
DOI: 10.1016/j.rmed.2022.107059

Abstract

This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV₁. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.

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Conflict of interest statement

Declaration of competing interest DJS is a PI for Nuvaira, USA and reports consultancy fees from Nuvaira paid to the institution. AV reports speaker fees from Nuvaira in the past. PS reports clinical trial expenses reimbursed to the host institutions in the past 36 months. CP reports payments for lectures and to CHUGA to conduct phase 3 trials from Nuvaira (AIRFLOW 2 and 3 trials), GSK, AZ, Boehringer Ingelheim, Novartis and Chiesi. JH and FH have nothing to disclose.

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Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Collaborators

Affiliations

Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

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