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Comment
. 2022 Dec 1;29(12):1613-1615.
doi: 10.1016/j.stem.2022.11.003.

A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle

Pier Lorenzo Puri  1
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A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle

Pier Lorenzo Puri. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Porpiglia et al.1 report on alterations in CD47 and THBS1 expression and function in aged muscle stem cells that disrupt their regeneration capacity. Targeting THBS1-CD47 cross-signaling is sufficient to reverse sarcopenia and restore muscle mass and function in aged mice.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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