Specialized cells for building tissue bridges
- PMID: 36459962
- DOI: 10.1016/j.stem.2022.11.009
Specialized cells for building tissue bridges
Abstract
Fang and colleagues provide a comprehensive transcriptomic analysis of the cell types occupying the interface between tendon and bone, the enthesis. They establish a framework for understanding enthesis maturation and identify a potent Gli1-lineage progenitor with clonogenicity and multipotency that improves enthesis healing in an adult injury model.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential.Cell Stem Cell. 2022 Dec 1;29(12):1669-1684.e6. doi: 10.1016/j.stem.2022.11.007. Cell Stem Cell. 2022. PMID: 36459968 Free PMC article.
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