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Comment
. 2022 Dec 1;82(23):4403-4404.
doi: 10.1016/j.molcel.2022.10.021.

Thou shalt not cleave DNA-only repress transcription: A compact Cas protein representing a new CRISPR-Cas subtype

Tridib Mahata  1 , Udi Qimron  2
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Comment

Thou shalt not cleave DNA-only repress transcription: A compact Cas protein representing a new CRISPR-Cas subtype

Tridib Mahata et al. Mol Cell. .
Free article

Abstract

Wu et al.1 characterize Cas12m, a compact Cas protein that silences transcription without cleaving DNA and is a prototype protein of the novel CRISPR-Cas subtype V-M.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • The miniature CRISPR-Cas12m effector binds DNA to block transcription.
    Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491

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