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Comment
. 2023 Apr;19(4):214-215.
doi: 10.1038/s41581-022-00656-y.

New insights into cognitive decline in chronic kidney disease

Wei Ling Lau  1 , Mark Fisher  2   3
Affiliations
Comment

New insights into cognitive decline in chronic kidney disease

Wei Ling Lau et al. Nat Rev Nephrol. 2023 Apr.

Abstract

Chronic kidney disease (CKD) is known to be associated with cognitive impairment, but the mechanisms that underlie this kidney–brain connection are unclear. A recent study provides evidence that CKD is an independent risk factor for cognitive decline due to cerebral small vessel disease.

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Figures

Fig. 1 ∣
Fig. 1 ∣. Mechanisms of microvascular injury in chronic kidney disease.
Interplay of factors in chronic kidney disease that lead to cerebral small vessel (microvascular) disease, which encompasses cerebral microhaemorrhages (microbleeds), small deep infarcts (lacunes), microinfarcts and white matter hyperintensities. Adapted with permission from ref., CCBY 4.0.
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References

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